US4292312A
Expired / Lapsed
US
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Method for preparing alloxan stable aqueous solutions and solutions resulting therefrom
Assignee: Individual
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Filing: 1980-06-13
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Granted: 1981-09-29
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Expires: 2000-06-13
Abstract
Abstract Stable aqueous injectable solutions comprising alloxan stabilized with a reducing sugar selected from the group consisting of levulose, glucose and lactose are disclosed.
Inventors
- 👤 Henri Griffon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K47/00; A61K47/06; A61K47/26; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A method for preparing a stable, aqueous solution of alloxan, which comprising: dissolving in an aqueous fluid a predetermined quantity by weight of alloxan and adding from about 5 to 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said fluid.
Claim 2
Independent Claim
55 words
A method for preparing a stable, aqueous solution of alloxan, which comprising: dissolving in an aqueous fluid a predetermined quantity by weight of alloxan and adding from about 5 to 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said fluid.
Claim 3
Dependent Claim
11 words
The method according to claim 1, wherein the sugar is levulose.
Claim 4
Dependent Claim
11 words
The method according to claim 1, wherein the sugar is glucose.
Claim 5
Dependent Claim
11 words
The method according to claim 1, wherein the sugar is lactose.
Claim 6
Independent Claim
85 words
A method for preparing a stable, injectable aqueous alloxan solution which comprises: dissolving in physiological serum a predetermined quantity by weight of alloxan, adding from about 5 to about 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said serum, filtering the serum, introducing said serum into a 5 ml ampule, sealing the ampule with a burner and sterilizing the ampule through tyndallization between about 60° C. to about 70° C.
Claim 7
Independent Claim
85 words
A method for preparing a stable, injectable aqueous alloxan solution which comprises: dissolving in physiological serum a predetermined quantity by weight of alloxan, adding from about 5 to about 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said serum, filtering the serum, introducing said serum into a 5 ml ampule, sealing the ampule with a burner and sterilizing the ampule through tyndallization between about 60° C. to about 70° C.
Claim 8
Independent Claim
79 words
A method for preparing stable, injectable aqueous alloxan solutions introduced in sterile ampullae, which comprises: dissolving in water a predetermined quantity by weight of alloxan, adding from about 5 to about 25 times by weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said water, filtering said water with a bacteriological membrane, introducing the water under a sterile atmosphere into an ampule and sealing said ampule with heat.
Claim 9
Independent Claim
79 words
A method for preparing stable, injectable aqueous alloxan solutions introduced in sterile ampullae, which comprises: dissolving in water a predetermined quantity by weight of alloxan, adding from about 5 to about 25 times by weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said water, filtering said water with a bacteriological membrane, introducing the water under a sterile atmosphere into an ampule and sealing said ampule with heat.
Claim 10
Dependent Claim
32 words
The method according to claim 6, which further comprises adding about 10 mg of pure anhydrous alloxan and about 50 mg of levulose for each 1 ml of water in said solutions.
Claim 11
Independent Claim
49 words
A method for preparing a stable aqueous solution containing a predetermined quantity by weight of alloxan, which comprises: adding from about 5 to about 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said solution.
Claim 12
Independent Claim
49 words
A method for preparing a stable aqueous solution containing a predetermined quantity by weight of alloxan, which comprises: adding from about 5 to about 25 times the weight of said alloxan of at least one sugar selected from the group consisting of levulose, glucose and lactose to said solution.
Claim 13
Dependent Claim
49 words
A pharmaceutical formulation comprising: a solution containing a predetermined quantity by weight of alloxan dissolved in water or physiological serum, said solution containing from about 5 to about 25 times the weight of said alloxan of a reducing sugar selected from the group consisting of levulose, glucose and lactose.
Claim 14
Dependent Claim
49 words
A pharmaceutical formulation comprising: a solution containing a predetermined quantity by weight of alloxan dissolved in water or physiological serum, said solution containing from about 5 to about 25 times the weight of said alloxan of a reducing sugar selected from the group consisting of levulose, glucose and lactose.
Claim 15
Dependent Claim
25 words
The pharmaceutical formulation according to claim 9, further comprising for each ml of water, about 10 mg of alloxan and about 50 mg of levulose.
References Cited (Backward Citations)
US3637640A
Cited
US3728454A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |