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US4291708A
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Apparatus and method for detection of tumors in tissue
Assignee: Yeda Research and Development Co Ltd
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Filing: 1978-11-02
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Granted: 1981-09-29
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Expires: 1998-11-02
Abstract
Abstract An apparatus for detecting tumors in living human breast tissue includes instrumentalities for determining the dielectric constants of a plurality of localized regions of living human breast tissue. These instrumentalities include a bridge which is provided with a circuit for automatically nulling the bridge while in operation. Instrumentalities are provided for measuring variations in the dielectric constants over a plurality of the regions and for indicating the possible presence of a tumor as result of the measurement. The apparatus may be utilized in carrying out a method of detecting tumors which includes the steps of applying a plurality of probe elements to human breast tissue for sensing characteristics of localized regions thereof, applying an electrical signal to the probe elements for determining dielectric constants of localized regions of the tissue, sensing variations in the dielectric constants and determining the rate-of-change of dielectric constant at each of the localized regions.
Inventors
- 👤 Ephraim H. Frei
- 👤 Bruce D. Sollish
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:50
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/05; A61B5/053; A61B5/0536; A61B5/0059; A61B5/0082; A61B5/0091; A61B5/43; A61B5/4306; A61B5/4312
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
72 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the dielectric constants of a plurality of localized regions of living human breast tissue including a bridge means having means for automatically nulling said brigde means while in operation; and means for measuring variations in said dielectric constants over a plurality of said regions and for indicating the possible presence of a tumor as a result of said measurement.
Claim 2
Dependent Claim
72 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the dielectric constants of a plurality of localized regions of living human breast tissue including a bridge means having means for automatically nulling said brigde means while in operation; and means for measuring variations in said dielectric constants over a plurality of said regions and for indicating the possible presence of a tumor as a result of said measurement.
Claim 3
Dependent Claim
54 words
Apparatus for detecting tumors according to claim 1 and wherein said determining means comprises: probe means; means for applying a swept frequency signal to said probe means; signal processing circuitry, coupled to said bridge for providing an output indication of dielectric constant of the localized region of breast tissue associated with said probe means.
Claim 4
Dependent Claim
21 words
Apparatus for detecting tumors according to claim 2 wherein said swept frequency signal varies in frequency between 0.1 and 10 KHz.
Claim 5
Dependent Claim
20 words
Apparatus according to claim 1 and also comprising means for recording a plurality of dielectric constant patterns for subsequent reference.
Claim 6
Dependent Claim
97 words
Apparatus according to claim 1 and wherein said determining means comprises: probe means comprising a plurality of probe elements; means for providing a swept frequency signal switching means for selectably and sequentially connecting individual ones of said plurality of probe elements to said bridge and for connecting said probe elements not currently connected to said bridge to said means for providing a swept frequency signal; and wherein said indiciating means comprises a cathode ray tube display; and wherein said apparatus also comprises microcomputer controlled recording means for recording the dielectric constant information produced by said indicating means.
Claim 7
Dependent Claim
126 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the dielectric constants of a plurality of localized regions of living human breast tissue; and means for indicating variations in said dielectric constants over a plurality of said regions, said variations indicating the possible presence of a tumor; and wherein said determining means comprises: probe means comprising a plurality of probe elements arranged for sensing different ones of said localized regions; switching means for selectably applying an electrical signal to said probe elements; a balancing bridge circuit coupled to said probe elements; and signal processing circuitry coupled to said balancing bridge for providing an output indication of dielectric constants of the localized regions of breast tissue associated with each of said probe elements.
Claim 8
Dependent Claim
126 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the dielectric constants of a plurality of localized regions of living human breast tissue; and means for indicating variations in said dielectric constants over a plurality of said regions, said variations indicating the possible presence of a tumor; and wherein said determining means comprises: probe means comprising a plurality of probe elements arranged for sensing different ones of said localized regions; switching means for selectably applying an electrical signal to said probe elements; a balancing bridge circuit coupled to said probe elements; and signal processing circuitry coupled to said balancing bridge for providing an output indication of dielectric constants of the localized regions of breast tissue associated with each of said probe elements.
Claim 9
Dependent Claim
17 words
Apparatus according to claim 6 and wherein said signal processing circuitry comprises an analog to digital converter.
Claim 10
Dependent Claim
17 words
Apparatus according to claim 6 and wherein said switching means comprises a multiplexer operated by a microcomputer.
Claim 11
Dependent Claim
41 words
Apparatus according to claim 6 and wherein said probe comprises an insulative housing and an 8×8 array of probe elements and wherein said switching means is operative to couple only one of said probe elements at a time to said bridge.
Claim 12
Dependent Claim
75 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the variation of the dielectric constant of localized regions of living human breast tissue as a function of frequency of a signal applied thereto and including automatic balancing bridge means which do not require nulling for each measurement; and means for indicating differences in said variation over a plurality of said localized regions, said differences indicating the possible presence of a tumor.
Claim 13
Dependent Claim
75 words
Apparatus for detecting tumors in living human breast tissue comprising: means for determining the variation of the dielectric constant of localized regions of living human breast tissue as a function of frequency of a signal applied thereto and including automatic balancing bridge means which do not require nulling for each measurement; and means for indicating differences in said variation over a plurality of said localized regions, said differences indicating the possible presence of a tumor.
Claim 14
Dependent Claim
67 words
Apparatus according to claim 10 and wherein said determining means comprises: probe means comprising a plurality of probe elements; means for providing a swept frequency signal; switching means for selectively and sequentially connecting individual ones of said plurality of probe elements to said balancing bridge and for connecting said probe elements not currently connected to said balancing bridge to said means for providing a swept frequency signal.
Claim 15
Dependent Claim
38 words
Apparatus according to claim 11 and wherein said indicating means comprises a cathode ray tube display and wherein said apparatus also comprises microcomputer controlled recording means for recording the dielectric constant variation information produced by said indicating means.
Claim 16
Independent Claim
91 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; and detecting a possible tumor by sensing variations in said dielectric constants over a plurality of said regions.
Claim 17
Independent Claim
91 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; and detecting a possible tumor by sensing variations in said dielectric constants over a plurality of said regions.
Claim 18
Dependent Claim
26 words
A method according to claim 13 and also comprising the step of: determining the dielectric constants of said localized regions at a plurality of signal frequencies.
Claim 19
Independent Claim
110 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electric signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and determining the rate of change of dielectric constant with frequency at each of said localized regions.
Claim 20
Independent Claim
110 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electric signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and determining the rate of change of dielectric constant with frequency at each of said localized regions.
Claim 21
Independent Claim
112 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and determining the rate of change of dielectric constant with log of frequency at each of said localized regions.
Claim 22
Independent Claim
112 words
A method for detecting tumors in living human breast tissue comprising the steps of: applying probe means comprising a plurality of probe elements to human breast tissue in vivo such that individual ones of said probe elements are arranged for sensing characteristics of individual localized regions of human breast tissue; selectably applying an electrical signal to said probe elements for determining the dielectric constants of said localized regions of living human breast tissue; sensing variations in said dielectric constants over a plurality of said regions to indicate the possible presence of a tumor; and determining the rate of change of dielectric constant with log of frequency at each of said localized regions.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |