US4288424A
Expired / Lapsed
US
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Generator for ionic gallium-68 based on column chromatography
Assignee: Massachusetts Institute of Technology
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Filing: 1979-01-15
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Granted: 1981-09-08
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Expires: 1999-01-15
Abstract
Abstract A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing 68 Ga-fluorides. The solution then is neutralized prior to administration.
Inventors
- 👤 Rudi D. Neirinckx
- 👤 Michael A. Davis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:36
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/12; A61K51/1282; G; G21; G21G; G21G1/00; G21G1/04; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
60 words
The process for obtaining a physiologically acceptable aqueous solution of gallium-68 which comprises binding 68 GeF 6 =to an anion-exchange resin from a hydrofluoric acid solution whereby gallium-68 fluorides are formed in situ from said 68 GeF 6 =, eluting said gallium-68 fluorides from said resin with an aqueous HF solution and neutralizing the aqueous HF solution containing gallium-68 fluorides.
Claim 2
Dependent Claim
60 words
The process for obtaining a physiologically acceptable aqueous solution of gallium-68 which comprises binding 68 GeF 6 =to an anion-exchange resin from a hydrofluoric acid solution whereby gallium-68 fluorides are formed in situ from said 68 GeF 6 =, eluting said gallium-68 fluorides from said resin with an aqueous HF solution and neutralizing the aqueous HF solution containing gallium-68 fluorides.
Claim 3
Dependent Claim
72 words
A kit for the preparation of a physiologically acceptable solution of gallium-68 from a resin column containing bound germanium 68 which comprises a first container having a volume of about 2 to 4 ml in which is aseptically and hermetically sealed a 0.005N to 0.01N HF solution and a second container having a volume of about 4 to 10 ml and in which is sealed a neutralizing agent for said acidic solution.
Claim 4
Dependent Claim
72 words
A kit for the preparation of a physiologically acceptable solution of gallium-68 from a resin column containing bound germanium 68 which comprises a first container having a volume of about 2 to 4 ml in which is aseptically and hermetically sealed a 0.005N to 0.01N HF solution and a second container having a volume of about 4 to 10 ml and in which is sealed a neutralizing agent for said acidic solution.
Claim 5
Dependent Claim
12 words
The kit of claim 2 wherein the second container is partially evacuated.
Claim 6
Dependent Claim
15 words
The kit of claim 3 wherein the second container is provided with a hypodermic syringe.
Claim 7
Dependent Claim
21 words
A generator for gallium-68 fluorides which comprises a column of an anion-exchange resin containing 68 GeF 6 =bound to said resin.
Claim 8
Dependent Claim
21 words
A generator for gallium-68 fluorides which comprises a column of an anion-exchange resin containing 68 GeF 6 =bound to said resin.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-07 | 1985-03-09 | 1985-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-07 | 1989-03-09 | 1989-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-07 | 1993-03-09 | 1993-09-08 | $7700.00 | Window Closed / Lapsed |