US4285964A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Salts of (+)-catechine, their preparation and use, and compositions containing these salts
Assignee: Continental Pharma Inc
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Filing: 1979-08-30
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Granted: 1981-08-25
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Expires: 1999-08-30
Abstract
Abstract A salt of (+)-catechin formed of the reaction product of (+)-catechin with at least a basic amino-acid, such as L-lysine and L-arginine; a hydrosoluble double salt is formed by the reaction product of (+)-catechin with a basic amino-acid, such as L-lysine and L-arginine, and another inorganic or organic acid.
Inventors
- 👤 Paul Niebes
- 👤 Andras Vincze
- 👤 Joseph Roba
- 👤 Georges Lambelin
- 👤 Daniel Matagne
- 👤 Etienne Hanon
- 👤 Michel Franz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:37
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D311/60; C07D311/62; A; A61; A61P; A61P43/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
26 words
A salt of (+)-catechin which is the reaction product of (+)-catechin with at least one basic amino-acid selected from the group consisting of L-lysine and L-arginine.
Claim 2
Dependent Claim
26 words
A salt of (+)-catechin which is the reaction product of (+)-catechin with at least one basic amino-acid selected from the group consisting of L-lysine and L-arginine.
Claim 3
Dependent Claim
43 words
A hydrosoluble double salt of (+)-catechin which is the reaction product of (+)-catechin, a basic amino-acid selected from the group consisting of L-lysine and L-arginine and another acid selected from the group consisting of hydrochloric acid, ascorbic acid, acetic acid and citric acid.
Claim 4
Dependent Claim
43 words
A hydrosoluble double salt of (+)-catechin which is the reaction product of (+)-catechin, a basic amino-acid selected from the group consisting of L-lysine and L-arginine and another acid selected from the group consisting of hydrochloric acid, ascorbic acid, acetic acid and citric acid.
Claim 5
Dependent Claim
20 words
A salt as claimed in claim 2, wherein the basic amino-acid is L-lysine and said other acid is hydrochloric acid.
Claim 6
Dependent Claim
20 words
A salt as claimed in claim 2, wherein the basic amino-acid is L-lysine and said other acid is ascorbic acid.
Claim 7
Dependent Claim
23 words
A salt as claimed in claim 2 wherein said (+)-catechin, said basic amino-acid and said other acid are present in substantially equivalent amounts.
Claim 8
Dependent Claim
39 words
A pharmaceutical composition for the treatment of diseases of the articular cartilage comprising, as active product, an effective amount of at least one hydrosoluble double salt of (+)-catechin as claimed in claim 2, in association with a suitable excipient.
Claim 9
Dependent Claim
44 words
An orally, topically, rectally or parenterally administerable pharmaceutical composition for the treatment of diseases of the articular cartilage comprising, as active product, an effective amount of at least one hydrosoluble salt of (+)-catechin as claimed in claim 1, in association with a suitable excipient.
Claim 10
Dependent Claim
47 words
A method for treating degenerative diseases of the connective tissue, which comprises administering a salt of (+)-catechin as claimed in claim 1 orally or rectally at a daily dosage of 1 to 4 g or intravenously or intra-articularly at a daily dosage of 5 to 50 mg.
Claim 11
Dependent Claim
48 words
A method for treating degenerative diseases of the connective tissue, which comprises administering a double salt of (+)-catechin as claimed in claim 2 orally or rectally at a daily dosage of 1 to 4 g or intravenously or intra-articularly at a daily dosage of 5 to 50 mg.
Claim 12
Dependent Claim
32 words
A method for treating degenerative diseases of the connective tissue which comprises topically administering a salt of (+)-catechin as claimed in claim 1 in an amount of 100 mg to 2 g.
Claim 13
Dependent Claim
66 words
The method of claim 8 wherein said salt of (+)-catechin is in the form of an orally, topically, rectally or parenterally administerable composition comprising, as active product, an effective amount of at least one hydrosoluble salt of (+)-catechin which is the reaction product of (+)-catechin with at least one basic amino-acid selected from the group consisting of L-lysine and L-arginine in association with a suitable excipient.
Claim 14
Dependent Claim
76 words
The method of claim 9 wherein said salt of (+)-catechin is in the form of a composition comprising, as active product, an effective amount of at least one hydrosoluble double salt of (+)-catechin which is the reaction product of (+)-catechin, a basic amino-acid selected from the group consisting of L-lysine and L-arginine and another acid selected from the group consisting of hydrochloric acid, ascorbic acid, acetic acid and citric acid, in association with a suitable excipient.
Claim 15
Dependent Claim
66 words
The method of claim 10 wherein said salt of (+)-catechin is in the form of an orally, topically, rectally or parenterally administerable composition comprising, as active product, an effective amount of at least one hydrosoluble salt of (+)-catechin which is the reaction product of (+)-catechin with at least one basic amino-acid selected from the group consisting of L-lysine and L-arginine in association with a suitable excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-24 | 1985-02-23 | 1985-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-24 | 1989-02-23 | 1989-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-24 | 1993-02-23 | 1993-08-25 | $7700.00 | Window Closed / Lapsed |