US4285857A
Expired / Lapsed
US
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Cyclic analogues of callidine
Assignee: Individual
•
Filing: 1979-09-26
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Granted: 1981-08-25
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Expires: 1999-09-26
Abstract
Abstract Novel cyclic analogues of callidine have the following general formula: ##STR1## wherein Pro is moiety of L-proline, Gly--that of glycine, Phe--phenylalanine, Arg--L-argenine; R is a residue of α- or ω-aminoacid or peptide; R 1 is a residue of α- or ω- amino-acid; R 2 is L-serine or glycine, the carbonyl group of arginine being connected either with R or with R 1 by means of a covalent peptide bond using the ω-amino group of the aminoacid located in the 1 or 2 position of the calladine sequence. The novel compounds according to the present invention possess a prolonged hypotensive effect of selective character.
Inventors
- 👤 Gunar I. Chipens
- 👤 Felix K. Mutulis
- 👤 Olga E. Lando
- 👤 Natalia V. Myshlyakova
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:08
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/18; A; A61; A61P; A61P9/00; A61P9/12; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/27
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
95 words
Cyclic analogues of callidine of the formula: ##STR7## wherein Pro is a moiety of L-proline, Gly - that of glycine, Phe is a moiety of L-phenylalanine; Arg - that of L-arginine; R is a residue of α- or ω-lysine or arginine; R 1 is a residue or α- or ω-lysine or arginine; R 2 is L-serine, and the carbonyl group of arginine is connected with either R or R 1 by means of a covalent peptide bond using the ω-amino group of the R or R 1 located at 1 or 2 position of callidine.
Claim 2
Dependent Claim
95 words
Cyclic analogues of callidine of the formula: ##STR7## wherein Pro is a moiety of L-proline, Gly - that of glycine, Phe is a moiety of L-phenylalanine; Arg - that of L-arginine; R is a residue of α- or ω-lysine or arginine; R 1 is a residue or α- or ω-lysine or arginine; R 2 is L-serine, and the carbonyl group of arginine is connected with either R or R 1 by means of a covalent peptide bond using the ω-amino group of the R or R 1 located at 1 or 2 position of callidine.
Claim 3
Dependent Claim
8 words
Cyclo-/N.sup.ε -callidine/of claim 1 of the formula: ##STR8##
Claim 4
Dependent Claim
10 words
N.sup.α -arginyl-cyclo-/(N.sup.ε -1-lysine, 6-glycine)bradikinin/of claim 1 of the formula: ##STR9##
Claim 5
Dependent Claim
7 words
Cyclo-/(ω-aminododecanoyl)bradikinin/of claim 1 of the formula: ##STR10##
Claim 6
Dependent Claim
7 words
Cyclo-/(ω-aminododecanoyl-ω-aminododecanoyl)bradikinin/of claim 1 of the formula: ##STR11##
References Cited (Backward Citations)
US3247181A
Cited
US3216992A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-24 | 1985-02-23 | 1985-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-24 | 1989-02-23 | 1989-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-24 | 1993-02-23 | 1993-08-25 | $7700.00 | Window Closed / Lapsed |