US4284779A
Expired / Lapsed
US
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Amino acid derivatives
Assignee: ER Squibb and Sons LLC
•
Filing: 1977-10-31
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Granted: 1981-08-18
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Expires: 1997-10-31
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Michael E. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:35
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07C; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/46; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D211/06; C07D211/36; C07D211/60; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
93 words
A compound of the formula ##STR14## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino(imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR15## A and B together form a (CH 2 ) p bridge which completes an unsubstituted ring of 6 atoms with the nitrogen and carbon to which they are joined or said ring substituted with a hydroxy group; m is 1,2,3 or 4; n is 0 or 1; and p is 4.
Claim 2
Dependent Claim
93 words
A compound of the formula ##STR14## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino(imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR15## A and B together form a (CH 2 ) p bridge which completes an unsubstituted ring of 6 atoms with the nitrogen and carbon to which they are joined or said ring substituted with a hydroxy group; m is 1,2,3 or 4; n is 0 or 1; and p is 4.
Claim 3
Dependent Claim
31 words
A compound of the formula ##STR16## and salts thereof, wherein R, R 1 , R 2 , R 3 , m and n have the same meaning as in claim 1.
Claim 4
Dependent Claim
46 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen, lower alkanoyl, or amino(imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl or benzoyl; m is 3 or 4 and n is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 3 is ##STR17##
Claim 6
Dependent Claim
46 words
A compound as in claim 2 wherein R is hydroxy; R 1 is hydrogen, lower alkanoyl or amino(imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl or benzoyl; m is 3 or 4 and n is 0 or 1.
Claim 7
Dependent Claim
10 words
A compound as in claim 1 wherein R is hydroxy.
Claim 8
Dependent Claim
10 words
A compound as in claim 2 wherein R is hydroxy.
Claim 9
Dependent Claim
22 words
A compound as in claim 2 wherein R is hydroxy and R 1 , R 2 and R 3 each is hydrogen.
Claim 10
Dependent Claim
28 words
A compound as in claim 2 wherein R is hydroxy, R 1 , R 2 and R 3 each is hydrogen, m is 3 and n is 1.
Claim 11
Dependent Claim
29 words
A compound as in claim 2 wherein R is hydroxy, R 2 and R 3 each is hydrogen, R 1 is amino(imino)methyl, m is 3 and n is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-17 | 1985-02-16 | 1985-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-17 | 1989-02-16 | 1989-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-17 | 1993-02-16 | 1993-08-18 | $7700.00 | Window Closed / Lapsed |