US4284723A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of epoxides and glycols from gaseous alkenes
Assignee: Novartis Vaccines and Diagnostics Inc
•
Filing: 1979-05-16
•
Granted: 1981-08-18
•
Expires: 1999-05-16
Abstract
Abstract Epoxides or glycols are produced by passing a gaseous olefin through a reaction mixture containing a halogenating enzyme, an oxidizing agent and a halide ion source whereby the olefin is converted to a halohydrin. The halohydrin is converted to an epoxide which may be converted by hydration to a glycol. Conversion of the halohydrin to an epoxide may be carried out enzymatically.
Inventors
- 👤 Saul L. Neidleman
- 👤 William F. Amon, Jr.
- 👤 John Geigert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:12
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0071; C07; C07C; C07C29/00; C07C29/09; C07C29/10; C12N9/0065; C12P; C12P17/00; C12P17/02; C12P7/00; C12P7/02; C12P7/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
74 words
A method for the manufacture of epoxides or glycols from a gaseous olefin selected from the group consisting of ethylene, propylene, isobutylene, butene-1, cis-butene-2, trans-butene-2, allene, and 1,3-butadiene, said method comprising providing in a reactor, a reaction mixture of a halogenating enzyme, an oxidizing agent, and a halide ion source, passing the gaseous olefin continuously through said reaction mixture to convert said olefin to a halohydrin, and converting said halohydrin to an epoxide enzymatically.
Claim 2
Independent Claim
74 words
A method for the manufacture of epoxides or glycols from a gaseous olefin selected from the group consisting of ethylene, propylene, isobutylene, butene-1, cis-butene-2, trans-butene-2, allene, and 1,3-butadiene, said method comprising providing in a reactor, a reaction mixture of a halogenating enzyme, an oxidizing agent, and a halide ion source, passing the gaseous olefin continuously through said reaction mixture to convert said olefin to a halohydrin, and converting said halohydrin to an epoxide enzymatically.
Claim 3
Dependent Claim
34 words
A method in accordance with claim 1 wherein said halogenating enzyme is a peroxidase derived from a source selected from the group consisting of the microorganism Caldariomyces fumago, seaweed, milk, thyroid, leukocytes and horseradish.
Claim 4
Dependent Claim
14 words
A method in accordance with claim 1 wherein said oxidizing agent is hydrogen peroxide.
Claim 5
Dependent Claim
18 words
A method in accordance with claim 1 wherein said halide ion source is a water soluble halide salt.
Claim 6
Dependent Claim
23 words
A method in accordance with claim 1 wherein the reaction is conducted within the pH range of from about 2.2 to about 8.0.
Claim 7
Dependent Claim
32 words
A method in accordance with claim 3 wherein said hydrogen peroxide is present during said reaction at a molar ratio of from about 0.5:1 to about 50:1 with respect to said olefin.
Claim 8
Dependent Claim
15 words
A method in accordance with claim 3 wherein said hydrogen peroxide is generated in situ.
Claim 9
Dependent Claim
29 words
A method according to claim 1 wherein said oxidizing agent is hydrogen peroxide generated in situ by means of methanol oxidase on a methanol substrate with coproduction of formaldehyde.
Claim 10
Dependent Claim
30 words
A method according to claim 1 wherein said oxidizing agent is hydrogen peroxide generated in situ by means of glucose oxidase on a glucose substrate with coproduction of gluconic acid.
Claim 11
Dependent Claim
73 words
A method in accordance with claim 1 wherein said halogenating enzyme is derived from a source selected from the group consisting of the microorganism Caldariomyces fumago, milk, and seaweed; said oxidizing agent is hydrogen peroxide; said halide ion source is selected from the group consisting of the chloride, bromide and iodide salts of sodium and potassium; and said reaction takes place in an essentially aqueous environment at ambient conditions of temperature and pressure.
Claim 12
Dependent Claim
17 words
A method in accordance with claim 1 wherein said epoxide is converted by hydration to a glycol.
Claim 13
Dependent Claim
25 words
A method in accordance with claim 1 wherein said halohydrin is converted to an epoxide in the same reactor in which said halohydrin is formed.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-17 | 1985-02-16 | 1985-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-17 | 1989-02-16 | 1989-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-17 | 1993-02-16 | 1993-08-18 | $7700.00 | Window Closed / Lapsed |