US4279795A
Expired / Lapsed
US
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Hydrophilic-hydrophobic graft copolymers for self-reinforcing hydrogels
Assignee: Kuraray Co Ltd
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Filing: 1973-12-28
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Granted: 1981-07-21
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Expires: 1993-12-28
Abstract
Abstract Materials for forming a hydrogel when contacted with water having improved anti-thrombogenic properties and a highly improved mechanical strength are obtained by the copolymerization of a free radical-polymerizable vinyl monomer capable of forming a hydrophilic polymer and a hydrophobic macromolecular compound having a chain-terminated polymerizable double bond and a molecular weight of 1,000 to 100,000.
Inventors
- 👤 Shuzo Yamashita
- 👤 Kyoichiro Shibatani
- 👤 Kiochi Takakura
- 👤 Kiyokazu Imai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:07
CPC Classifications
C; C08; C08F; C08F290/00; C08F290/02; C08F290/04; A; A61; A61L; A61L27/00; A61L27/14; A61L27/16; A61L27/50; A61L27/58; A61L33/00; A61L33/06; A61L33/064; B; B01; B01D; B01D71/00; B01D71/06; B01D71/38; B01D71/381; B01D71/40; B01D71/401; B01D71/76; B01D71/80; Y; Y10; Y10S; Y10S524/00; Y10S524/916
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
88 words
A copolymer for a self-reinforced and highly bio-compatible hydrogel which comprises (1) a hydrophilic polymer backbone moiety from a free radical polymerizable vinyl monomer capable of forming a hydrophilic polymer and (2) graft moieties attached to said backbone moiety from a hydrophobic macromolecular compound, 5 to 80% based on the weight of the copolymer, having a chain-terminated polymerizable double bond and a molecular weight of 1,000 to 100,000, said copolymer being swelled with water in a degree of an equilibrium water absorption of at least 10% by weight.
Claim 2
Dependent Claim
88 words
A copolymer for a self-reinforced and highly bio-compatible hydrogel which comprises (1) a hydrophilic polymer backbone moiety from a free radical polymerizable vinyl monomer capable of forming a hydrophilic polymer and (2) graft moieties attached to said backbone moiety from a hydrophobic macromolecular compound, 5 to 80% based on the weight of the copolymer, having a chain-terminated polymerizable double bond and a molecular weight of 1,000 to 100,000, said copolymer being swelled with water in a degree of an equilibrium water absorption of at least 10% by weight.
Claim 3
Dependent Claim
67 words
A copolymer as defined by claim 1, wherein said free radical-polymerizable monomer capable of forming a hydrophilic polymer is a monomer represented by the general formula: ##STR5## wherein R 1 represents a hydrogen atom or a methyl group, wherein R 2 is an alkylene group or --CH 2 CH 2 (OCH 2 CH 2 ) n --, and wherein n is an integer of 1 to 30.
Claim 4
Dependent Claim
14 words
A copolymer as defined by claim 1, wherein said hydrophobic macromolecular compound is polystyrene.
Claim 5
Dependent Claim
24 words
A copolymer as defined by claim 1, wherein said hydrophobic macromolecular compound is selected from the group consisting of polymethyl methacrylate and polymethyl acrylate.
Claim 6
Dependent Claim
11 words
Articles for biomedical purposes prepared from the copolymer of claim 1.
Claim 7
Dependent Claim
101 words
A hydrogel material having a degree of water absorption of at least 10% by weight consisting essentially of a copolymer comprising (1) a backbone moiety of a monomer of the formula: ##STR6## wherein R 1 is a hydrogen atom or a methyl group, wherein R 2 is an alkylene group or --CH 2 CH 2 (OCH 2 CH 2 ) n --, and wherein n is an integer of 1 to 30 and (2) graft moieties attached to said backbone moiety of a hydrophobic polymer having a chain terminated polymerizable double bond and a molecular weight of from 1,000 to 100,000.
Claim 8
Dependent Claim
101 words
A hydrogel material having a degree of water absorption of at least 10% by weight consisting essentially of a copolymer comprising (1) a backbone moiety of a monomer of the formula: ##STR6## wherein R 1 is a hydrogen atom or a methyl group, wherein R 2 is an alkylene group or --CH 2 CH 2 (OCH 2 CH 2 ) n --, and wherein n is an integer of 1 to 30 and (2) graft moieties attached to said backbone moiety of a hydrophobic polymer having a chain terminated polymerizable double bond and a molecular weight of from 1,000 to 100,000.
Claim 9
Dependent Claim
22 words
A hydrogel material as defined by claim 6, wherein said hydrophobic polymer is selected from the group consisting of polystyrene and poly-α-methylstyrene.
Claim 10
Dependent Claim
24 words
A hydrogel material as defined by claim 6, wherein said hydrophobic polymer is selected from the group consisting of polymethyl methacrylate and polymethyl acrylate.
Claim 11
Dependent Claim
44 words
A hydrogel material as defined in claim 6, wherein said hydrophobic polymer is represented by the formula: ##STR7## wherein R is an alkyl group, X is a hydrogen atom or an alkyl group and wherein n is an integer of from 10 to 1,000.
Claim 12
Dependent Claim
37 words
A hydrogel material as defined by claim 6, wherein said monomer is selected from the group consisting of hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, hydroxybutyl acrylate, hydroxybutyl methacrylate, polyethylene glycol monoacrylate and polyethylene glycol monomethacrylate.
Claim 13
Dependent Claim
13 words
A shaped article prepared from the hydrogel material as defined by claim 6.
Claim 14
Dependent Claim
78 words
A hydrogel material as defined by claim 10, wherein said copolymer also contains an amount of a comonomer which is copolymerizable with said monomer, said amount, in moles, being less than the amount, in moles, of said monomer wherein said copolymerizable monomer is selected from the group consisting of acrylic acid, methacrylic acid, methoxyethyl acrylate, methoxyethyl methacrylate, ethyl acrylate, ethyl methacrylate, propyl acrylate, propyl methacrylate, n-butyl acrylate, n-butyl methacrylate, α-methylstyrene, ethylene, propylene, butene, isoprene, butadiene, and maleic anhydride.
Claim 15
Dependent Claim
55 words
A hydrogel material as defined by claim 6, wherein said first monomer is 2-hydroxyethyl methacrylate and said hydrophobic polymer is represented by the formula: ##STR8## wherein R is an alkyl group, X is a hydrogen atom or an alkyl group, and wherein n is an integer which represents a molecular weight of 1,000 to 100,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-20 | 1985-01-19 | 1985-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-20 | 1989-01-19 | 1989-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-20 | 1993-01-19 | 1993-07-21 | $7700.00 | Window Closed / Lapsed |