US4278664A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preventative treatment for Otitis externae
Assignee: CLEAVE RUTH M VAN
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Filing: 1978-02-06
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Granted: 1981-07-14
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Expires: 1998-02-06
Abstract
Abstract A preventative composition for Otitis externae, commonly referred to as "Swimmer's Ear," and for eliminating the discomfort of water remaining in the external canal, which comprises applying to the skin surface of the external auditory canal of a patient's ear, a pharmaceutically safe, liquid, nonionic, substantially water insoluble, aqueous surface tension reducing agent.
Inventors
- 👤 Jon S. Van Cleave
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:26
CPC Classifications
A; A61; A61F; A61F11/00; A61K; A61K31/00; A61K31/74; A61K47/00; A61K47/06; A61K47/26; A61K9/00; A61K9/0012; A61K9/0046
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
65 words
A composition for preventive treatment for swimmer's ear said composition comprising, a pharmaceutically safe, liquid, non-ionic, substantially water insoluble aqueous surface tension reducing agent, in combination with an effective buffering amount of, a pharmaceutically safe non-skin irritating acidifying agent, and a pharmaceutically acceptable medicinal agent which is non-irritating, in an amount which is effective to prevent said surfactant from providing a medium for bacterial growth.
Claim 2
Dependent Claim
65 words
A composition for preventive treatment for swimmer's ear said composition comprising, a pharmaceutically safe, liquid, non-ionic, substantially water insoluble aqueous surface tension reducing agent, in combination with an effective buffering amount of, a pharmaceutically safe non-skin irritating acidifying agent, and a pharmaceutically acceptable medicinal agent which is non-irritating, in an amount which is effective to prevent said surfactant from providing a medium for bacterial growth.
Claim 3
Dependent Claim
14 words
The composition of claim 1 wherein said surface active agent is polyoxyethylene sorbitol oleate.
Claim 4
Dependent Claim
44 words
The composition of claim 2 wherein said boric acid is added within the range of from 0.1% to about 1.5% by weight of said surface active agent, to provide a pH within the range of from about 5 to about 6 to said composition.
Claim 5
Dependent Claim
26 words
The composition of claim 3 wherein said boric acid is added at a level of from 0.1% by weight to 1.0% by weight of said surfactant.
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein said medicinal agent is selected from the group consisting of methyl and propyl esters of para-hydroxybenzoic acid.
Claim 7
Dependent Claim
32 words
The composition of claim 5 wherein said esters are present at a percentage with level by weight of the surfactant within the range of from 0.1% up to about 2.0% by weight.
Claim 8
Dependent Claim
28 words
The composition of claim 6 wherein both methyl and propyl esters of para-hydroxybenzoic acid are present with the ratio of methyl to propyl being about 2 to 1.
Claim 9
Dependent Claim
15 words
The composition of claim 1 wherein said pharmaceutically safe, non-skin irritating acid is boric acid.
Claim 10
Dependent Claim
40 words
The composition of claim 1 wherein said pharmaceutically safe liquid non-ionic substantially water insoluble surface tension reducing agent is selected from the group consisting of those having an ether linkage, an ester linkage, an ester-ether linkage and an amide linkage.
Claim 11
Dependent Claim
99 words
A composition for preventive treatment for swimmer's ear, said composition comprising, a pharmaceutically safe, liquid, non-ionic substantially water insoluble aqueous surface tension reducing agent selected from the group consisting of those having an ether linkage, an ester linkage, an ester-ether linkage and an amide linkage, in combination with from about 1% to about 1.5% by weight of said surface active agent of a pharmaceutically safe, non-skin irritating acid, and from about 0.1% to about 2.0% by weight of said surface active agent of a medicinal agent selected from the group consisting of methyl and propyl esters of parahydroxybenzoic acid.
Claim 12
Dependent Claim
99 words
A composition for preventive treatment for swimmer's ear, said composition comprising, a pharmaceutically safe, liquid, non-ionic substantially water insoluble aqueous surface tension reducing agent selected from the group consisting of those having an ether linkage, an ester linkage, an ester-ether linkage and an amide linkage, in combination with from about 1% to about 1.5% by weight of said surface active agent of a pharmaceutically safe, non-skin irritating acid, and from about 0.1% to about 2.0% by weight of said surface active agent of a medicinal agent selected from the group consisting of methyl and propyl esters of parahydroxybenzoic acid.
Claim 13
Dependent Claim
28 words
The composition of claim 10 wherein both methyl and propyl esters of parahydroxybenzoic acid are present with the ratio of methyl to propyl being about 2 to 1.
References Cited (Backward Citations)
US3812251A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-13 | 1985-01-12 | 1985-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-13 | 1989-01-12 | 1989-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-13 | 1993-01-12 | 1993-07-14 | $7700.00 | Window Closed / Lapsed |