US4268630A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microbiological production of ketones from C3 -C6 alkanes
Assignee: ExxonMobil Technology and Engineering Co
•
Filing: 1979-03-30
•
Granted: 1981-05-19
•
Expires: 1999-03-30
Abstract
Abstract A process is disclosed for the microbiological production of ketones from C3-C6 alkanes by contacting C3-C6 alkanes under aerobic conditions with resting microbial cells derived from a methylotrophic microorganism or enzyme preparation derived from said cells, wherein the microorganism has been previously grown under aerobic conditions in a nutrient medium containing methane or dimethyl ether.
Inventors
- 👤 Ramesh N. Patel
- 👤 Ching-Tsang Hou
- 👤 Allen I. Laskin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:07
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0006; C12P; C12P7/00; C12P7/24; C12P7/26; C12P7/28; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/858
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
115 words
A process for the microbiological conversion of a C 3 -C 6 n-alkane to the corresponding methyl ketone, comprising oxidizing said alkane by contacting a reaction medium containing a C 3 -C 6 n-alkane, under aerobic conditions, in the presence of resting or washed microbial cells derived from a bacterial methylotrophic microorganism or an enzyme preparation derived from said cells, in the absence of a growth medium for said cells and under conditions such that at least a portion of the alkane molecule is oxidized to the corresponding methyl ketone in isolatable amounts by said cells or enzyme preparation, wherein said microorganism has been previously grown under aerobic conditions in a nutrient medium containing methane.
Claim 2
Dependent Claim
115 words
A process for the microbiological conversion of a C 3 -C 6 n-alkane to the corresponding methyl ketone, comprising oxidizing said alkane by contacting a reaction medium containing a C 3 -C 6 n-alkane, under aerobic conditions, in the presence of resting or washed microbial cells derived from a bacterial methylotrophic microorganism or an enzyme preparation derived from said cells, in the absence of a growth medium for said cells and under conditions such that at least a portion of the alkane molecule is oxidized to the corresponding methyl ketone in isolatable amounts by said cells or enzyme preparation, wherein said microorganism has been previously grown under aerobic conditions in a nutrient medium containing methane.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein said microorganisms are obligate or facultative methylotrophs.
Claim 4
Dependent Claim
25 words
The process of claim 2 wherein said microorganisms belong to the genera selected from the group consisting of Methylosinus, Methylocystis, Methylomonas, Methylobacter, Methylococcus and Methylobacterium.
Claim 5
Dependent Claim
49 words
The process of claim 2 wherein said microorganisms are species selected from the group consisting of: Methylosinus trichosporium, Methylosinus sporium, Methylocystis parvus, Methylomonas methanica, Methylomonas albus, Methylmonas streptobacterium, Methylomonas agile, Methylomonas rubrum, Methylomonas rosaceus, Methylobacter chrooccum, Methylobacter bovis, Methylobacter capsulatus, Methylobacter vinelandii, Methylococcus capsulatus, Methylococcus minimus, and Methylobacterium organophilum.
Claim 6
Dependent Claim
79 words
The process of claim 2 wherein said microorganisms are strains having the designations selected from the group consisting of: Methylosinus trichosporium OB3b (NRRL B-11,196); Methylosinus sporium 5 (NRRL B-11,197); Methylocystis parvus OBBP (NRRL B-11,198); Methylomonas methanica S 1 (NRRL B-11,199); Methylomonas albus BG8 (NRRL B-11,200); Methylobacter capsulatus Y (NRRL B-11,201); Methylococcus capsulatus (Texas) ATCC 19069; Methylobacterium organophilum sp. nov. (ATCC 27,886); Methylomonas sp. AJ-3670 (FERM P-2400); Methylococcus 999 (NCIB Accession No. 11,083); and Methylomonas SM3 (NCIB Accession No. 11,084).
Claim 7
Dependent Claim
19 words
The process of claim 1 wherein said enzyme preparation is a cell-free particulate fraction of said resting microbial cells.
Claim 8
Dependent Claim
21 words
The process of claims 1, 2, 3, 4, 5 or 6 wherein the reaction medium includes reduced nicotinamide ademine dinucleotide (NADH).
Claim 9
Dependent Claim
16 words
The process of claim 1 wherein a secondary alcohol is additionally obtained with said methyl ketone.
Claim 10
Dependent Claim
12 words
The process of claim 1 wherein the conversion is carried out batchwise.
Claim 11
Dependent Claim
15 words
The process of claim 1 wherein the conversion is carried out in a continuous manner.
References Cited (Backward Citations)
US3326771A
Cited
US3344037A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-18 | 1984-11-17 | 1985-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-18 | 1988-11-17 | 1989-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-18 | 1992-11-17 | 1993-05-19 | $7700.00 | Window Closed / Lapsed |