US4268501A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Suppositories containing a compound having bronchodilator activity
Assignee: Astellas Pharma Inc
•
Filing: 1979-12-05
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Granted: 1981-05-19
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Expires: 1999-12-05
Abstract
Abstract A stable suppository useful as an antiasthmatic agent containing 3-formylamino-4-hydroxy- alpha -[N-(1-methyl-2-p-methoxyphenylethyl)aminomethyl]benzyl alcohol.1/2fumarate monohydrate, polyvinyl pyrrolidone, and at least one of cyclodextrin, dextran and magnesium metasilicate aluminate together with a suppository base.
Inventors
- 👤 Yutaka Konno
- 👤 Shigeo Kawamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K31/00; A61K31/13; A61K31/135; Y; Y10; Y10S; Y10S424/00; Y10S424/15
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
52 words
A stable suppository comprising: (A) an anti-asthmatic effective amount of 3-formylamino-4-hydroxy-α-benzyl alcohol.1/2fumarate mono-hydrate as the active ingredient, compounded with (B) a stabilizing effective amount of stabilizing components comprising polyvinyl pyrrolidone and at least one member selected from the group consisting of cyclodextrin, dextran and magnesium metasilicate aluminate, and (C) a suppository base.
Claim 2
Dependent Claim
52 words
A stable suppository comprising: (A) an anti-asthmatic effective amount of 3-formylamino-4-hydroxy-α-benzyl alcohol.1/2fumarate mono-hydrate as the active ingredient, compounded with (B) a stabilizing effective amount of stabilizing components comprising polyvinyl pyrrolidone and at least one member selected from the group consisting of cyclodextrin, dextran and magnesium metasilicate aluminate, and (C) a suppository base.
Claim 3
Dependent Claim
22 words
The stable suppository as claimed in claim 1 wherein said suppository heat base is a glycerol triester of a higher fatty acid.
Claim 4
Dependent Claim
26 words
The stable suppository as claimed in claim 1 wherein said member is β-cyclodextrin and said suppository base is a glycerol triester of a higher fatty acid.
Claim 5
Dependent Claim
54 words
The stable suppository as claimed in claim 1 wherein the amount of polyvinyl pyrrolidone is 1-200 parts by weight based on the weight of the active ingredient and the amount of at least one of cyclodextrin, dextran and magnesium metasilicate aluminate is 20-500 parts by weight based on the weight of the active ingredient.
Claim 6
Dependent Claim
45 words
The stable suppository as claimed in claim 3 wherein the amount of polyvinyl pyrrolidone is 1-200 parts by weight based on the weight of the active ingredient and the amount of β-cyclodextrin is 20-500 parts by weight based on the weight of the active ingredient.
Claim 7
Dependent Claim
54 words
The stable suppository as claimed in claim 1 wherein the amount of polyvinyl pyrrolidone is 10-50 parts by weight based on the weight of the active ingredient and the amount of at least one of cyclodextrin, dextran and magnesium metasilicate aluminate is 50-200 parts by weight based on the weight of the active ingredient.
Claim 8
Dependent Claim
45 words
The stable suppository as claimed in claim 3 wherein the amount of polyvinyl pyrrolidone is 10-50 parts by weight based on the weight of the active ingredient and the amount of β-cyclodextrin is 50-200 parts by weight based on the weight of the active ingredient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-18 | 1984-11-17 | 1985-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-18 | 1988-11-17 | 1989-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-18 | 1992-11-17 | 1993-05-19 | $7700.00 | Window Closed / Lapsed |