US4267272A
Expired / Lapsed
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Prostatic acid phosphatase immuno assay
Assignee: Baxter Healthcare Corp
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Filing: 1979-11-05
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Granted: 1981-05-12
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Expires: 1999-11-05
Abstract
Abstract Prostatic acid phosphatase is immunologically unstable under typical laboratory conditions. Thus it is necessary to combine a stabilizing composition with samples taken for immunological assay of prostatic acid phosphatase content, and to similarly stabilize prostatic acid phosphatase-containing reagents in kits used to assay the enzyme.
Inventors
- 👤 Lee Josephson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:24
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/573; Y; Y10; Y10S; Y10S435/00; Y10S435/962; Y10S435/963; Y10S435/967
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
55 words
In an immunoassay for PAP wherein the amount of PAP in PAP standards is determined, the improvement comprising contacting the standards with a composition for stabilizing the enzymatic activity of PAP under conditions that would otherwise render the standard PAP ineffective in displacing tracer PAP from PAP antibody thereby also stablizing the PAP immunological activity.
Claim 2
Dependent Claim
55 words
In an immunoassay for PAP wherein the amount of PAP in PAP standards is determined, the improvement comprising contacting the standards with a composition for stabilizing the enzymatic activity of PAP under conditions that would otherwise render the standard PAP ineffective in displacing tracer PAP from PAP antibody thereby also stablizing the PAP immunological activity.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the composition is an antibody to PAP.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the composition is an acid.
Claim 5
Dependent Claim
19 words
In an immunoassay method for PAP, the improvement comprising PAP standards having a pH of about from5.0 to 5.5.
Claim 6
Dependent Claim
19 words
In an immunoassay method for PAP, the improvement comprising PAP standards having a pH of about from5.0 to 5.5.
Claim 7
Dependent Claim
14 words
The method of claim 4 wherein the PAP standard is at about pH 5.5.
Claim 8
Dependent Claim
17 words
The immunoassay method of claim 4 wherein the standard further contains an inhibitor of PAP enzyme activity.
Claim 9
Dependent Claim
10 words
The method of claim 6 wherein the inhibitor is L-tartrate.
Claim 10
Dependent Claim
14 words
The immunoassay method of claims 1 or 4 wherein the standard includes human serum.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-11 | 1984-11-10 | 1985-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-11 | 1988-11-10 | 1989-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-11 | 1992-11-10 | 1993-05-12 | $7700.00 | Window Closed / Lapsed |