US4267178A
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Disubstituted piperazines
Assignee: Science Union et Cie
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Filing: 1979-02-26
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Granted: 1981-05-12
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Expires: 1999-02-26
Abstract
Abstract Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2, m is 0 or 1, and Het is pyridyl, pyrimidinyl, pyrazinyl, thiazolyl or thiadiazolyl each optionally substituted by one or more alkyl having from 1 to 5 carbon atoms inclusive. These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of hypertension.
Inventors
- 👤 Gilbert Regnier
- 👤 Michel Laubie
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:08
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/14; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
70 words
A compound selected from the group consisting of: disubstituted piperazines of the formula: ##STR8## in which: n is selected from 1 and 2; m is selected from 0 and 1, and Het is selected from the group consisting of pyridyl, pyrimidinyl, pyrazinyl, thiazolyl and thiadiazolyl and each of these radicals mono- and poly-substituted by alkyl having from 1 to 5 carbon atoms inclusive; and, physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
70 words
A compound selected from the group consisting of: disubstituted piperazines of the formula: ##STR8## in which: n is selected from 1 and 2; m is selected from 0 and 1, and Het is selected from the group consisting of pyridyl, pyrimidinyl, pyrazinyl, thiazolyl and thiadiazolyl and each of these radicals mono- and poly-substituted by alkyl having from 1 to 5 carbon atoms inclusive; and, physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
58 words
Compounds of claim 1, of the formula I, in which n and m have the meanings given in claim 1 and Het is selected from the group consisting of pyridyl, pyrimidinyl and thiazolyl and each of these radicals mono- and poly-substituted by alkyl having from 1 to 5 carbon atoms inclusive, and physiologically tolerable acid addition salts thereof.
Claim 4
Dependent Claim
12 words
A compound of claim 1 which is 1-(6,7-methylenedioxy-1,2,3,4-tetrahydro-2-naphtyl)-4-(2-pyrimidinyl) piperazine, and its monomethanesulfonate.
Claim 5
Dependent Claim
9 words
A compound of claim 1 which is 1-(6,7-methylenedioxy-1,2,3,4-tetrahydro-2-naphthyl)-4-(2-pyridyl) piperazine.
Claim 6
Dependent Claim
13 words
A compound of claim 1 which is 1-(6,7-methylene dioxy-1,2,3,4-tetrahydro-2-naphthyl)-4-(2-thiazolyl) piperazine, and its dihydrochloride.
Claim 7
Dependent Claim
12 words
A compound of claim 1 is 1-(5,6-methylenedioxy-2-indanyl)-4-(2-pyridyl) piperazine, and its monomethane sulfonate.
Claim 8
Dependent Claim
27 words
An antihypertensive pharmaceutical composition containing as active ingredient a compound of claim 1 in an amount of 1 to 300 mg, together with a suitable pharmaceutical carrier.
Claim 9
Dependent Claim
34 words
A method for treating a living animal body afflicted with hypertension, comprising the step of administering an amount of a compound of claim 1 which is effective for the alleviation of the said condition.
References Cited (Backward Citations)
US2543972A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-11 | 1984-11-10 | 1985-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-11 | 1988-11-10 | 1989-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-11 | 1992-11-10 | 1993-05-12 | $7700.00 | Window Closed / Lapsed |