US4267138A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coating ensuring a controlled release of active ingredients of biologically active compositions, particularly pharmaceutical compositions and a process for preparation of biologically active compositions ensuring controlled release of active ingredients
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1977-09-19
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Granted: 1981-05-12
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Expires: 1997-09-19
Abstract
Abstract A coating ensuring the controlled release of a biological active ingredient, which can be incorporated in the coating or is surrounded thereby, consists of a varnish-forming polymer selected from the group which consists of cellulose triacetate containing polyethylene glycol as an emollient and vinyl chloride-vinyl acetate copolymer with glycerol as an emollient, and an aqueous phase dispersed in the polymer and consisting of particles of a diameter up to 20 microns, the aqueous phase making up 2% to 30% of the volume of the coating. The active ingredient is preferably a pharmaceutical agent affecting the circulatory system or a psychotropic agent.
Inventors
- 👤 Janos Dobo
- 👤 Erzsebet Takacs
- 👤 Gyozo Hortobagyi
- 👤 Marianne Skvorecz nee Hajnoczy
- 👤 Ilona Kolbe
- 👤 Katalin Hoffmann nee Vas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/2853; A61K9/2072; A61K9/2086; A61K9/209; A61K9/282; A61K9/284; A61K9/286; A61K9/2866; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
142 words
A process for preparing a pharmaceutical for gastrointestinal release, comprising the steps of: (a) forming a water-in-oil emulsion from a solution of a varnish-forming polymer substantially unaffected by exposure to gastrointestinal juices in a water-immiscible solvent and an aqueous phase dispersed in the organic phase in particles not more than 20 microns in diameter, said aqueous phase constituting 2 to 30% of the total volume and containing at least one substance selected from the group which consists of a plasticizer, a wetting agent, a buffer and a hygroscopic substance; (b) coating granules of a pharmaceutical suitable for oral administration with the emulsion formed during step a) and evaporating the solvent to form a coating which substantially retains the aqueous phase of the emulsion dispersed throughout the varnish-forming polymer; and (c) agglomerating the granules coated during step b) into a pharmaceutical dosage unit.
Claim 2
Dependent Claim
142 words
A process for preparing a pharmaceutical for gastrointestinal release, comprising the steps of: (a) forming a water-in-oil emulsion from a solution of a varnish-forming polymer substantially unaffected by exposure to gastrointestinal juices in a water-immiscible solvent and an aqueous phase dispersed in the organic phase in particles not more than 20 microns in diameter, said aqueous phase constituting 2 to 30% of the total volume and containing at least one substance selected from the group which consists of a plasticizer, a wetting agent, a buffer and a hygroscopic substance; (b) coating granules of a pharmaceutical suitable for oral administration with the emulsion formed during step a) and evaporating the solvent to form a coating which substantially retains the aqueous phase of the emulsion dispersed throughout the varnish-forming polymer; and (c) agglomerating the granules coated during step b) into a pharmaceutical dosage unit.
Claim 3
Dependent Claim
21 words
The process defined in claim 1 further comprising the step of compressing the coated granules agglomerated during step (c) into tablets.
Claim 4
Dependent Claim
17 words
The process defined in claim 1 wherein the pharmaceutical is an agent acting upon the circulatory system.
Claim 5
Dependent Claim
19 words
The process defined in claim 3 wherein the agent acting upon the circulatory system is apovincaminic acid ethyl ester.
Claim 6
Dependent Claim
17 words
The process defined in claim 3 wherein the agent acting upon the circulatory system is bamethane sulfate.
Claim 7
Dependent Claim
17 words
The process defined in claim 3 wherein the agent acting upon the circulatory system is isosorbide dinitrate.
Claim 8
Dependent Claim
14 words
The process defined in claim 1 wherein the pharmaceutical is a psychotropically active substance.
Claim 9
Dependent Claim
13 words
The process defined in claim 7 wherein the psychotropically active substance is reserpine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-11 | 1984-11-10 | 1985-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-11 | 1988-11-10 | 1989-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-11 | 1992-11-10 | 1993-05-12 | $7700.00 | Window Closed / Lapsed |