US4265885A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anthracyclines containing branched-chain amino-deoxy sugars
Assignee: Pfizer Italia SRL
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Filing: 1979-10-05
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Granted: 1981-05-05
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Expires: 1999-10-05
Abstract
Abstract A new class of antitumor glycoside antibiotics of the formula (IA): <IMAGE> (IA) wherein R is hydrogen or hydroxy; and X is <IMAGE> These compounds are prepared, using novel intermediates, by condensing the appropriate aglycone and branched-chain aminodeoxy sugar to form the alpha -glycosidic linkage.
Inventors
- 👤 Alberto Bargiotti
- 👤 Giuseppe Cassinelli
- 👤 Federico Arcamone
- 👤 Aurelio DIMarco
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:39
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
42 words
A compound of general formula I: ##STR15## in which R represents a hydrogen atom or a hydroxy group, one of R 1 and R 2 represents a methyl group and the other of R 1 and R 2 represents a methoxy group.
Claim 2
Dependent Claim
42 words
A compound of general formula I: ##STR15## in which R represents a hydrogen atom or a hydroxy group, one of R 1 and R 2 represents a methyl group and the other of R 1 and R 2 represents a methoxy group.
Claim 3
Dependent Claim
2 words
4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride.
Claim 4
Dependent Claim
2 words
4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride.
Claim 5
Dependent Claim
2 words
4'-epi-4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride.
Claim 6
Dependent Claim
2 words
4'-epi-4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride.
Claim 7
Dependent Claim
2 words
4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
Claim 8
Dependent Claim
2 words
4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
Claim 9
Dependent Claim
2 words
4'-epi-4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
Claim 10
Dependent Claim
2 words
4'-epi-4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
Claim 11
Dependent Claim
33 words
A pharmaceutical composition containing a therapeutically effective amount of an anthracycline glycoside of general formula I according to any of claims 1 to 5 in combination with a therapeutically acceptable diluent or carrier.
Claim 12
Dependent Claim
50 words
A compound of the formula: ##STR16## where X is H 3 C when Y is H 3 CO or OH and X is H 3 CO or OH when Y is H 3 C; where Z is OCH 3 ; H, OR; H; Cl; or OH; where R is ##STR17##
Claim 13
Dependent Claim
50 words
A compound of the formula: ##STR16## where X is H 3 C when Y is H 3 CO or OH and X is H 3 CO or OH when Y is H 3 C; where Z is OCH 3 ; H, OR; H; Cl; or OH; where R is ##STR17##
Claim 14
Dependent Claim
8 words
The hydrochloride of the compounds of claim 7.
Claim 15
Dependent Claim
2 words
2,3,6-Trideoxy-4-C-methyl-4-O-methyl-3-trifluoroacetamido-L-lyxo-hexopyranosyl chloride.
Claim 16
Dependent Claim
2 words
2,3,6-Trideoxy-4-C-methyl-4-O-methyl-3-trifluoroacetamido-L-lyxo-hexopyranosyl chloride.
Claim 17
Dependent Claim
2 words
2,3,6-Trideoxy-4-C-methyl-4-O-methyl-3-trifluoroacetamido-L-arabino-hexopyranosyl chloride.
Claim 18
Dependent Claim
2 words
2,3,6-Trideoxy-4-C-methyl-4-O-methyl-3-trifluoroacetamido-L-arabino-hexopyranosyl chloride.
Claim 19
Independent Claim
36 words
A method for treating leukemia P 388 in a host comprising treating the host with a therapeutically effective amount of a compound selected from the group consisting of 4'-C-methyl-4'-O-methyl-daunorubicin, 4'-epi-4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride; 4-C-methyl-4'-O-methyl-doxorubicin hydrochloride and 4'-epi-4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
Claim 20
Independent Claim
36 words
A method for treating leukemia P 388 in a host comprising treating the host with a therapeutically effective amount of a compound selected from the group consisting of 4'-C-methyl-4'-O-methyl-daunorubicin, 4'-epi-4'-C-methyl-4'-O-methyl-daunorubicin hydrochloride; 4-C-methyl-4'-O-methyl-doxorubicin hydrochloride and 4'-epi-4'-C-methyl-4'-O-methyl-doxorubicin hydrochloride.
References Cited (Backward Citations)
US4183919A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-04 | 1984-11-03 | 1985-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-04 | 1988-11-03 | 1989-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-04 | 1992-11-03 | 1993-05-05 | $7700.00 | Window Closed / Lapsed |