US4264620A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihypertensive 5-substituted 2-pyrrolidinecarboxylic acids
Assignee: Santen Pharmaceutical Co Ltd
•
Filing: 1979-07-23
•
Granted: 1981-04-28
•
Expires: 1999-07-23
Abstract
Abstract Derivatives of 5-substituted 2-pyrrolidinecarboxylic acid which have the general formula ##STR1## are useful in compositions as antihypertensive agents.
Inventors
- 👤 Jun-ichi Iwao
- 👤 Masayuki Oya
- 👤 Eishin Kato
- 👤 Yoichi Kawashima
- 👤 Hiroshi Masuda
- 👤 Tadashi Iso
- 👤 Takihisa Chiba
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 12:36
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; A; A61; A61P; A61P9/00; A61P9/12; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
36 words
A compound of the formula ##STR5## wherein R 1 is phenyl or hydroxyphenyl; R 2 is hydrogen or benzoyl; Q is straight or branched alkylene with 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
36 words
A compound of the formula ##STR5## wherein R 1 is phenyl or hydroxyphenyl; R 2 is hydrogen or benzoyl; Q is straight or branched alkylene with 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
A compound as in claim 1 wherein R 1 is phenyl, 2-hydroxyphenyl or 4-hydroxyphenyl.
Claim 4
Dependent Claim
11 words
A compound as in claim 2 wherein R 2 is hydrogen.
Claim 5
Dependent Claim
23 words
A composition comprising a compound of claim 1 in an amount sufficient to reduce blood pressure and at least one pharmaceutically acceptable excipient.
Claim 6
Dependent Claim
18 words
A method for reducing blood pressure which comprises administering an effective amount of a compound of claim 1.
Claim 7
Dependent Claim
11 words
A compound as in claim 2 wherein R 2 is benzoyl.
Claim 8
Dependent Claim
21 words
A compound as in any one of claims 1, 2, 3, and 6 wherein Q is --CH 2 CH 2 --.
Claim 9
Dependent Claim
21 words
A compound as in any one of claims 1, 2, 3 and 6 wherein Q is --CH(CH 3 )CH 2 --.
Claim 10
Dependent Claim
8 words
1-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-5-phenyl-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 11
Dependent Claim
8 words
1-[(2S)-3-Mercapto-2-methylpropanoyl]-5-phenyl-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 12
Dependent Claim
8 words
α-1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 13
Dependent Claim
8 words
β-1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 14
Dependent Claim
8 words
α-5-(2-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 15
Dependent Claim
8 words
.beta.-5-(2-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 16
Dependent Claim
8 words
α-1-(S-Benzoyl-1-mercaptopropanoyl)-5-(4-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 17
Dependent Claim
8 words
β-1-(S-Benzoyl-3-mercaptopropanoyl)-5-(4-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 18
Dependent Claim
8 words
α-5-(4-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 19
Dependent Claim
8 words
.beta.-5-(4-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 20
Dependent Claim
8 words
α-1-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 21
Dependent Claim
8 words
β-1-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 22
Dependent Claim
8 words
α-5-(2-Hydroxyphenyl)-1-[(2S)-3-mercapto-2-methylpropanoyl]-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 23
Dependent Claim
8 words
β-5-(2-Hydroxyphenyl)-1-[(2S)-3-mercapto-2-methylpropanoyl]-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 24
Dependent Claim
10 words
α 1 -1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 25
Dependent Claim
10 words
β 1 -1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 26
Dependent Claim
10 words
α 2 -1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 27
Dependent Claim
10 words
β 2 -1-(S-Benzoyl-3-mercaptopropanoyl)-5-(2-hydroxyphenyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 28
Dependent Claim
10 words
α 1 -5-(2-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 29
Dependent Claim
10 words
α 2 -5-(2-Hydroxyphenyl)-1-(3-mercaptopropanoyl)-2-pyrrolidinecarboxylic acid of the formula of claim 1.
Claim 30
Dependent Claim
19 words
A compound as in any one of claims 1, 2, 3 and 6 wherein Q is --CH 2 --.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-27 | 1984-10-27 | 1985-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-27 | 1988-10-27 | 1989-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-27 | 1992-10-27 | 1993-04-28 | $7700.00 | Window Closed / Lapsed |