US4264574A
Expired / Lapsed
US
⏱️ 0.0 years remaining
New galenical form of administration of betahistine and its derivatives and the preparation thereof
Assignee: Individual
•
Filing: 1980-02-19
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Granted: 1981-04-28
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Expires: 2000-02-19
Abstract
Abstract A new galenical form of administration of betahistine and its derivatives, its preparation method and pharmaceutical products containing this new galenical form.
Inventors
- 👤 Jean S. Cherqui
- 👤 Alain C. Djiane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
79 words
A therapeutically useful and pharmacologically acceptable oral depot medicament in the form of substantially uniformly sized spheroidal particles containing 2-methylaminoethyl pyridinemethanesulphonate as the active ingredient thereof comprising (a) an inactive core of pharmaceutically acceptable carrier material; (b) at least two sets of sequential bipartite layers on said core comprising an inner layer of the active ingredient and an outer layer of a dialysis membrane, said membrane being substantially insoluble in neutral or acid environments but soluble above pH 7.
Claim 2
Dependent Claim
79 words
A therapeutically useful and pharmacologically acceptable oral depot medicament in the form of substantially uniformly sized spheroidal particles containing 2-methylaminoethyl pyridinemethanesulphonate as the active ingredient thereof comprising (a) an inactive core of pharmaceutically acceptable carrier material; (b) at least two sets of sequential bipartite layers on said core comprising an inner layer of the active ingredient and an outer layer of a dialysis membrane, said membrane being substantially insoluble in neutral or acid environments but soluble above pH 7.
Claim 3
Dependent Claim
42 words
A medicament in accordance with claim 1 wherein the inner layer of said sequential bipartite layer outwardly of the first dialysis membrane outwardly of the inactive core, additionally comprises pharmaceutically acceptable and pharmaceutically-inert carrier material upon which the active ingredient is adsorbed.
Claim 4
Dependent Claim
31 words
A medicament in accordance with claim 1 wherein said dialysis material is a material selected from the group consisting of an anionic polymerizate of methacrylic acid and methacrylic esters, and shellac.
Claim 5
Dependent Claim
17 words
A medicament in accordance with claim 3 wherein said medicament is further encapsulated in pharmaceutically acceptable capsules.
Claim 6
Dependent Claim
27 words
A method of treating vertigo in patients suffering from Meniere's syndrome which comprises administering to said patients an antivertigo effective amount of a composition of claim 1.
Claim 7
Dependent Claim
21 words
The method of claim 5 which comprises administering to said patients up to 48 mg per day of said active ingredient.
Claim 8
Dependent Claim
30 words
A method for treating Meniere's disease in patients suffering from said condition which consists in administering to said patients a safe but effective amount of the composition of claim 1.
Claim 9
Dependent Claim
29 words
The method of claim 7 in which the safe but effective amount of the composition of claim 1 incorporates from 30 to 40 mg of betahistine methanesulphonate per day.
Claim 10
Dependent Claim
30 words
A method for treating cerebrovascular deficiencies in patients suffering from said deficiency which consists in administering to said patients a safe but effective amount of a composition of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-27 | 1984-10-27 | 1985-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-27 | 1988-10-27 | 1989-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-27 | 1992-10-27 | 1993-04-28 | $7700.00 | Window Closed / Lapsed |