US4260736A
Expired / Lapsed
US
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Steroid hormone-antitumor derivatives
Assignee: Kureha Corp
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Filing: 1979-08-01
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Granted: 1981-04-07
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Expires: 1999-08-01
Abstract
Abstract A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C 1 -C 4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of --O--, --COO--, --CONH--, --NH-- or ##STR2##
Inventors
- 👤 Kiro Asano
- 👤 Humio Tamura
- 👤 Hiromitsu Tanaka
- 👤 Satoru Enomotol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:04
CPC Classifications
C; C07; C07J; C07J41/00; C07J41/0033; C07J41/0038; C07J1/00; C07J1/0051; C07J1/0066; C07J1/007; C07J1/0074; C07J41/0072; C07J43/00; C07J43/003
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
5 words
A compound of the formula:
Claim 2
Dependent Claim
5 words
A compound of the formula:
Claim 3
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-(10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-hydroxy-1,3,5(10)-estratriene-17.beta.-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside
Claim 4
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-(10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-hydroxy-1,3,5(10)-estratriene-17.beta.-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside
Claim 5
Dependent Claim
1 words
3-Glycolyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-benzoyloxy-1,3,5(10)-estratriene-17β-oxycarbony
Claim 6
Dependent Claim
1 words
3-Glycolyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-benzoyloxy-1,3,5(10)-estratriene-17β-oxycarbony
Claim 7
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-acetoxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside.
Claim 8
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-acetoxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside.
Claim 9
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-propionyloxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside.
Claim 10
Dependent Claim
1 words
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3'-(3-propionyloxy-1,3,5(10)-estratriene-17β-oxycarbonylmethyl)amino-2',3',6'-trideoxy-γ-L-lyxo-hexapyranoside.
References Cited (Backward Citations)
US4150126A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-04-06 | 1984-10-06 | 1985-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-04-06 | 1988-10-06 | 1989-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-04-06 | 1992-10-06 | 1993-04-07 | $7700.00 | Window Closed / Lapsed |