US4259495A
Expired / Lapsed
US
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Process for producing 2,3,5,6-tetrachloropyridine
Assignee: Novartis Corp
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Filing: 1979-09-10
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Granted: 1981-03-31
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Expires: 1999-09-10
Abstract
Abstract A novel process for producing 2,3,5,6-tetrachloropyridine is described. In this process, pentachloropyridine is reacted, in an alkanephosphonic acid dialkyl ester (dialkyl alkane phosphonate) having 1 to 4 carbon atoms in each of the alkyl groups or in a phosphoric acid trialkyl ester (trialkyl phosphate) having 1 to 4 carbon atoms in each of the alkyl groups as the solvent, at 60° to 120° C., in the presence of 1.4 to 2.8 mols, per mol of pentachloropyridine, of an ammonium salt of an inorganic or organic acid, with 1.2 to 1.6 gram atoms of zinc per mol of pentachloropyridine, with selective dechlorination of the pentachloropyridine in the 4-position occurring. 2,3,5,6-Tetrachloropyridine is a valuable commercial product, which can be used for producing insecticidal formulations. Furthermore, 2,3,5,6-tetrachloropyridine is used as intermediate for the production of herbicidally effective α-[4-(3',5',6'-trichloropyrid-2'-yloxy)-phenoxy]-alkanecarboxylic acids and derivatives thereof. There are also described novel ammonium salts of methanephosphonic acid monomethyl ester, in the presence of which the selective dechlorination of pentachloropyridine in the 4-position can be advantageously performed.
Inventors
- 👤 Claus D. Weis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:11
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/61; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4071; C07F9/4075
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
228 words
A process for producing 2,3,5,6 -tetrachloropyridine by dechlorination of pentachloropyridine, which process comprises reacting pentachloropyridine, in an alkanephosphonic acid dialkyl ester having 1 to 4 carbon atoms in each of the alkyl groups or in a phosphoric acid trialkyl ester having 1 to 4 carbon atoms in each of the alkyl groups as the solvent, at 60° to 120° C., in the presence of 1.4 to 2.8 mols, per mol of pentachloropyridine, of an ammonium salt of an inorganic or organic acid, with 1.2 to 1.6 gram atoms of zinc per mol of pentrachoropyridine, said ammonium salt having the formula ##STR3## in which R 1 , R 2 , R 3 and R 4 can be identical or different and are each hydrogen, alkyl having 1 to 4 carbon atoms, or phenyl which can be substituted by halogen, by alkyl groups have 1 to 4 carbon atoms or by alkoxy groups having 1 to 4 carbon atoms, X is an anion from the group: chloride, bromide, sulfate, hydrogen sulfate, phosphate, hydrogen phosphate, dihydrogen phosphate, carbonate, hydrogen carbonate, acetate, propionate, butyrate, isobutyrate, oxalate, benzoate, alkanephosphonate having 1 to 4 carbon atoms in the alkyl group and alkane- or benzene sulfonate having 1 to 4 carbon atoms in the alkyl group, and n is 1 to 3 and corresponds to the number of negative charges of the respective anion X.
Claim 2
Dependent Claim
228 words
A process for producing 2,3,5,6 -tetrachloropyridine by dechlorination of pentachloropyridine, which process comprises reacting pentachloropyridine, in an alkanephosphonic acid dialkyl ester having 1 to 4 carbon atoms in each of the alkyl groups or in a phosphoric acid trialkyl ester having 1 to 4 carbon atoms in each of the alkyl groups as the solvent, at 60° to 120° C., in the presence of 1.4 to 2.8 mols, per mol of pentachloropyridine, of an ammonium salt of an inorganic or organic acid, with 1.2 to 1.6 gram atoms of zinc per mol of pentrachoropyridine, said ammonium salt having the formula ##STR3## in which R 1 , R 2 , R 3 and R 4 can be identical or different and are each hydrogen, alkyl having 1 to 4 carbon atoms, or phenyl which can be substituted by halogen, by alkyl groups have 1 to 4 carbon atoms or by alkoxy groups having 1 to 4 carbon atoms, X is an anion from the group: chloride, bromide, sulfate, hydrogen sulfate, phosphate, hydrogen phosphate, dihydrogen phosphate, carbonate, hydrogen carbonate, acetate, propionate, butyrate, isobutyrate, oxalate, benzoate, alkanephosphonate having 1 to 4 carbon atoms in the alkyl group and alkane- or benzene sulfonate having 1 to 4 carbon atoms in the alkyl group, and n is 1 to 3 and corresponds to the number of negative charges of the respective anion X.
Claim 3
Dependent Claim
23 words
A process according to claim 1, wherein the alkanephosphonic acid dialkyl ester used is methanephosphonic acid dimethyl ester or ethanephosphonic acid diethyl ester.
Claim 4
Dependent Claim
23 words
A process according to claim 1, wherein the phosphoric acid trialkyl ester used is phosphoric acid trimethyl ester or phosphoric acid triethyl ester.
Claim 5
Dependent Claim
19 words
A process according to claim 1, wherein the dechlorination of the pentachloropyridine is performed at 85° to 90° C.
Claim 6
Dependent Claim
27 words
A process according to claim 1, wherein there is used an ammonium salt of O-methyl-methanephosphonic acid of the formula ##STR4## in which R is hydrogen or methyl.
Claim 7
Dependent Claim
35 words
A process according to claim 1, wherein the ammonium salt used is: ammonium chloride, ammonium sulfate, ammonium carbonate, the ammonium salt of methanephosphonic acid monomethyl ester or the tetramethylammonium salt of methanephosphonic acid monomethyl ester.
Claim 8
Dependent Claim
29 words
A process according to claim 1, wherein, with the use of methanephosphonic acid dialkyl ester as solvent, there are used 1.6 mols of ammonium salt per mol of pentachloropyridine.
Claim 9
Dependent Claim
34 words
A process according to claim 1, wherein, with the use of ethanephosphonic acid dialkyl ester or trialkyl phosphate as solvent, there are used 2.6 to 2.8 mols of ammonium salt per mol of pentachloropyridine.
Claim 10
Dependent Claim
20 words
A process according to claim 1, wherein 1.20 to 1.30 gram atoms of zinc are used per mol of pentachloropyridine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-30 | 1984-09-29 | 1985-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-30 | 1988-09-29 | 1989-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-30 | 1992-09-29 | 1993-03-31 | $7700.00 | Window Closed / Lapsed |