US4259329A
Expired / Lapsed
US
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17-Cyclobutylmethyl-3-hydroxy-β-methyl-6-methylene morphinane, and methods of treating pain with them
Assignee: Bayer Corp
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Filing: 1980-04-21
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Granted: 1981-03-31
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Expires: 2000-04-21
Abstract
Abstract Disclosed are 6-methylene-morphinan compounds corresponding to the formula: ##STR1## wherein R 1 and R 3 are H or methyl and R 2 is cyclopropylmethyl or cyclobutylmethyl. These compounds are useful as mixed analgesics/narcotic antagonists.
Inventors
- 👤 Michael P. Kotick
- 👤 Joseph O. Polazzi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:20
CPC Classifications
C; C07; C07D; C07D221/00; C07D221/02; C07D221/22; C07D221/28
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
6 words
17-cyclobutylmethyl-3-hydroxy-8β-methyl-6-methylene morphinane of the formula: ##STR10##
Claim 2
Dependent Claim
6 words
17-cyclobutylmethyl-3-hydroxy-8β-methyl-6-methylene morphinane of the formula: ##STR10##
Claim 3
Dependent Claim
16 words
The compound of claim 1 in the form of its nontoxic, pharmaceutically acceptable acid addition salt.
Claim 4
Dependent Claim
18 words
The compound of claim 1 which is in the form of the tartrate, hydrobromide, hydrochloride or maleate salt.
Claim 5
Dependent Claim
29 words
A therapeutic method of treating pain in an individual requiring such treatment which comprises administering to such individual an effective amount of a compound characterized by the formula: ##STR11##
Claim 6
Dependent Claim
29 words
A therapeutic method of treating pain in an individual requiring such treatment which comprises administering to such individual an effective amount of a compound characterized by the formula: ##STR11##
Claim 7
Dependent Claim
22 words
The method of claim 4 in which the compound is administered in the form of its nontoxic, pharmaceutically acceptable acid addition salt.
Claim 8
Dependent Claim
20 words
The method of claim 4 wherein the compound is in the form of its tartrate, hydrobromide, hydrochloride or maleate salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-30 | 1984-09-29 | 1985-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-30 | 1988-09-29 | 1989-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-30 | 1992-09-29 | 1993-03-31 | $7700.00 | Window Closed / Lapsed |