Abstract Covers a process for the preparation of a beta -aminopropionanide of the formula <IMAGE> wherein R1 is H or methyl, n is an integer of 2 to 6 and R2 and R3, taken singly are hydrogen or lower alkyl groups containing 1 to 4 carbon atoms or R2 and R3, taken jointly are combined with the nitrogen atom to form a heterocyclic group selected from the groups consisting of morpholine, pyrrolidine and piperidine ring groups; which process comprises reacting in the presence of an alkali or alkaline earth metal salt of a strong acid having a pKa of less than about 2.0 acting as a catalyst a tertiaryaminoalkyl amine of the formula: <IMAGE> where R2, R3 and n are as above with an acrylic or methacrylic compound of the formula: <IMAGE> where R1 is as above and R4 is lower alkyl and recovering said beta -aminopropionamide.
A process for the preparation of a β-aminopropionamide of the formula ##STR6## wherein R 1 is H or methyl, n is an integer of 2 to 6 and R 2 and R 3 , taken singly are hydrogen or lower alkyl groups or R 2 and R 3 , taken jointly when combined with the nitrogen atom form a heterocyclic group selected from the group consisting of morpholine, pyrrolidine and piperidine ring groups, which process comprises reacting in the presence of an alkali or alkaline earth metal salt of a strong acid having a pK a of about 2 acting as a catalyst, a tertiaryaminoalkyl amine of the formula. ##STR7## where R 2 , R 3 and n are as above with an acrylic or methacrylic compound of the formula: ##STR8## where R 1 is as above and R 4 is lower alkyl and recovering said β-aminopropionamide.
Claim 2
Dependent Claim
147 words
A process for the preparation of a β-aminopropionamide of the formula ##STR6## wherein R 1 is H or methyl, n is an integer of 2 to 6 and R 2 and R 3 , taken singly are hydrogen or lower alkyl groups or R 2 and R 3 , taken jointly when combined with the nitrogen atom form a heterocyclic group selected from the group consisting of morpholine, pyrrolidine and piperidine ring groups, which process comprises reacting in the presence of an alkali or alkaline earth metal salt of a strong acid having a pK a of about 2 acting as a catalyst, a tertiaryaminoalkyl amine of the formula. ##STR7## where R 2 , R 3 and n are as above with an acrylic or methacrylic compound of the formula: ##STR8## where R 1 is as above and R 4 is lower alkyl and recovering said β-aminopropionamide.
Claim 3
Dependent Claim
13 words
The process of claim 1 where R 2 and R 3 are methyl.
Claim 4
Dependent Claim
7 words
The process of claim 2 where n=3.
Claim 5
Dependent Claim
10 words
The process of claim 3 where R 1 is methyl.
Claim 6
Dependent Claim
10 words
The process of claim 4 where R 4 is methyl.
Claim 7
Dependent Claim
14 words
The process of claim 1 which is run at a temperature of 20°-200° C.
Claim 8
Dependent Claim
12 words
The process of claim 1 wherein said temperature range is 60°-140° C.
Claim 9
Dependent Claim
15 words
The process of claim 1 wherein said catalyst is a magnesium calcium or barium halide.
Claim 10
Dependent Claim
12 words
The process of claim 1 wherein said catalyst is a lithium halide.