US4254768A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypodermic syringe
Assignee: Individual
•
Filing: 1979-09-14
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Granted: 1981-03-10
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Expires: 1999-09-14
Abstract
Abstract A multiple barrel hypodermic syringe is provided for mixing materials contained in the barrels prior to use. A typical two barrel syringe comprises a lower barrel for containing a sterile material such as a lyophilizable product, and an upper barrel containing a liquid diluent. The two barrels can be completely disengaged for separate replacement, alteration or reconstitution, etc., of their contents, if necessary. One or more slot vents are provided along either barrel to enable release of air, gas, moisture, etc., within the lower barrel when they are partially engaged. Upon further engagement in a sterile environment, the slot vents will be totally occluded by the mating surfaces of the two barrels; this enables the syringe to be sealed and the contents stored for future use. The hypodermic syringe of this invention also enables a lyophilization process to be carried out in situ followed by storage.
Inventors
- 👤 Perla J. Ty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:56
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/178; A61M5/31; A61M5/3129; A61M5/28; A61M5/284; A61M2005/3123
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
188 words
A multiple barrel hypodermic syringe, comprising: a lower barrel having an outlet port for a hypodermic needle; an upper barrel providing a removable hypodermic plunger at its upper end and a displaceable or frangible bottom seal at its lower end, the upper barrel being adapted to contain liquids or solids therein, the upper and lower barrels being sealed from each other solely by means of the bottom seal; the upper and lower barrels being sized for sliding engagement along their respective outer and inner peripheries; one or more grooves defining vent slots which connect the lower barrel interior solely to atmosphere, the vent grooves extending along a barrel periphery to permit gas, air and moisture to escape solely to atmosphere when the barrels are partly engaged, the vent slots being occluded to seal the lower barrel and its contents from the atmosphere, when the two barrels are substantially engaged; the upper and lower barrels being adapted to contain a liquid or solid, whereby disengagement of the barrels and hypodermic plunger enables separate removal and replacement of material from its respective barrel, without contamination of material in adjacent barrels.
Claim 2
Dependent Claim
188 words
A multiple barrel hypodermic syringe, comprising: a lower barrel having an outlet port for a hypodermic needle; an upper barrel providing a removable hypodermic plunger at its upper end and a displaceable or frangible bottom seal at its lower end, the upper barrel being adapted to contain liquids or solids therein, the upper and lower barrels being sealed from each other solely by means of the bottom seal; the upper and lower barrels being sized for sliding engagement along their respective outer and inner peripheries; one or more grooves defining vent slots which connect the lower barrel interior solely to atmosphere, the vent grooves extending along a barrel periphery to permit gas, air and moisture to escape solely to atmosphere when the barrels are partly engaged, the vent slots being occluded to seal the lower barrel and its contents from the atmosphere, when the two barrels are substantially engaged; the upper and lower barrels being adapted to contain a liquid or solid, whereby disengagement of the barrels and hypodermic plunger enables separate removal and replacement of material from its respective barrel, without contamination of material in adjacent barrels.
Claim 3
Dependent Claim
15 words
The hypodermic syringe of claim 1 in which the solid or liquid is a pharmaceutical.
Claim 4
Dependent Claim
40 words
The hypodermic syringe of claim 1 including flange members disposed on the upper and lower barrels, and adapted to contact each other when the barrels are substantially engaged; and, an elastomeric ring engaging the flanges, thereby sealing the lower barrel.
Claim 5
Dependent Claim
37 words
The hypodermic syringe of claim 1, the upper and lower barrels being partially engaged, thereby exposing a vent slot; the lower barrel containing a lyophilizable material, the said syringe being adapted for an in situ lyophilization process.
Claim 6
Dependent Claim
16 words
The hypodermic syringe of claim 1, comprising means to seal the syringe following the lyophilization process.
Claim 7
Dependent Claim
208 words
A process for the in situ lyophilization of a material, which comprises carrying out the lyophilization process in a multiple barrel hypodermic syringe, including: a lower barrel having an outlet port for a hypodermic needle; an upper barrel providing a removable hypodermic plunger at its upper end, and a displaceable or frangible bottom seal at its lower end, the upper barrel being adapted to contain liquids or solids therein, the upper and lower barrels being sealed from each other solely by means of the bottom seal; the upper and lower barrels being sized for sliding engagement along their respective outer and inner peripheries; one or more grooves defining vent slots which connect the lower barrel interior solely to atmosphere, the vent grooves extending along a barrel periphery to permit gas, air and moisture to escape during lyophilization solely to atmosphere when the barrels are partly engaged, the vent slots being occluded to seal the lower barrel and its contents from the atmosphere, when the two barrels are substantially engaged; the upper and lower barrels being adapted to contain a liquid or solid, whereby disengagement of the barrels and hypodermic plunger enables separate removal and replacement of material from its respective barrel, without contamination of material in adjacent barrels.
Claim 8
Dependent Claim
208 words
A process for the in situ lyophilization of a material, which comprises carrying out the lyophilization process in a multiple barrel hypodermic syringe, including: a lower barrel having an outlet port for a hypodermic needle; an upper barrel providing a removable hypodermic plunger at its upper end, and a displaceable or frangible bottom seal at its lower end, the upper barrel being adapted to contain liquids or solids therein, the upper and lower barrels being sealed from each other solely by means of the bottom seal; the upper and lower barrels being sized for sliding engagement along their respective outer and inner peripheries; one or more grooves defining vent slots which connect the lower barrel interior solely to atmosphere, the vent grooves extending along a barrel periphery to permit gas, air and moisture to escape during lyophilization solely to atmosphere when the barrels are partly engaged, the vent slots being occluded to seal the lower barrel and its contents from the atmosphere, when the two barrels are substantially engaged; the upper and lower barrels being adapted to contain a liquid or solid, whereby disengagement of the barrels and hypodermic plunger enables separate removal and replacement of material from its respective barrel, without contamination of material in adjacent barrels.
Claim 9
Dependent Claim
14 words
The process of claim 6 in which the lower barrel is sealed following lyophilization.
Claim 10
Dependent Claim
52 words
The process of claim 6 in which the hypodermic syringe includes: flange members disposed on the upper and lower barrels, and adapted to contact each other when the barrels are substantially engaged; and, an elastomeric ring adapted to engage the flanges, thereby sealing the lower barrel upon completion of the lyophilization process.
Claim 11
Dependent Claim
13 words
The process of claim 6 in which the lyophilized material is a pharmaceutical.
References Cited (Backward Citations)
US3016896A
Cited
US3348546A
Cited
US3255752A
Cited
US3279654A
Cited
US3337041A
Cited
US3756390A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-09 | 1984-09-08 | 1985-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-09 | 1988-09-08 | 1989-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-09 | 1992-09-08 | 1993-03-10 | $7700.00 | Window Closed / Lapsed |