US4254114A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Control of pyrophosphate microorganisms with organophosphonates
Assignee: Procter and Gamble Co
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Filing: 1979-01-02
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Granted: 1981-03-03
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Expires: 1999-01-02
Abstract
Abstract A method of selectively controlling pyrophosphate-utilizing microorganisms comprises contacting said microorganisms with an organism controlling amount of certain organophosphonate compounds. Accordingly, a method of treating amoebiasis in a human or lower animal comprises administering to a human or lower animal in need of such treatment a safe and effective amount of such organophosphonate compound. Similarly, a method of selectively controlling Propionibacteria species in the manufacture of cheese comprises incorporating an organism controlling amount of an organophosphonate compound in the raw materials for said cheese.
Inventors
- 👤 Keith C. Triebwasser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A01; A01N; A01N57/00; A01N57/18; A01N57/20; A01N57/22; A61P; A61P33/00; A61P33/02; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
155 words
A method for treating amoebiasis comprising administering to a human or lower animal in need of such treatment from about 0.1 to about 5 milligrams/kilogram body weight/day of a geminal diphosphonate compound having the formula ##STR4## wherein n is an integer from 1 to about 10, R 1 is selected from the group consisting of hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, napthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) and --CH 2 CH(PO 3 H 2 ) 2 , and R 2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , and --CH 2 CH 2 PO 3 H 2 , or a pharmaceutically-acceptable salts and mixtures thereof.
Claim 2
Independent Claim
155 words
A method for treating amoebiasis comprising administering to a human or lower animal in need of such treatment from about 0.1 to about 5 milligrams/kilogram body weight/day of a geminal diphosphonate compound having the formula ##STR4## wherein n is an integer from 1 to about 10, R 1 is selected from the group consisting of hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenyl, napthyl, phenylethenyl, benzyl, halogen, amino, dimethylamino, diethylamino, N-hydroxy-N-ethylamino, acetylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , --CH(PO 3 H 2 )(OH) and --CH 2 CH(PO 3 H 2 ) 2 , and R 2 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , and --CH 2 CH 2 PO 3 H 2 , or a pharmaceutically-acceptable salts and mixtures thereof.
Claim 3
Dependent Claim
55 words
A method according to claim 1 wherein the geminal diphosphonate compound is a member selected from the group consisting of ethane-1-hydroxy-1,1-diphosphonic acid, dichloromethane diphosphonic acid, methane hydroxy diphosphonic acid, nonane 1,1-diphosphonic acid, aminomethane diphosphonic acid, ethane-1-amino-1,1-diphosphonic acid, methane diphosphonic acid, nonane-1-hydroxy-1,1-diphosphonic acid, propane-3-amino-1,1-diphosphonic acid, the pharmaceutically acceptable salts of the above compounds, and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-02 | 1984-09-01 | 1985-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-02 | 1988-09-01 | 1989-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-02 | 1992-09-01 | 1993-03-03 | $7700.00 | Window Closed / Lapsed |