US4253997A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-ovulatory decapeptides
Assignee: Wyeth LLC
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Filing: 1979-12-17
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Granted: 1981-03-03
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Expires: 1999-12-17
Abstract
Abstract The compounds D-p-Glu-D-Phe-D-Nal(1)-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-Gly-NH2 where X is D-Nal(1), D-Trp, D-Phe, D-Tyr, D-Lys, D-Met, D-Ala or D-Pgl and pharmaceutically acceptable salts thereof exhibit antiovulatory activity in female mammals and are useful contraceptive agents.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:33
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13; Y10S930/28
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
24 words
A compound of the formula: D-p-Glu-D-Phe-D-Nal(1)-Ser-Tyr-X-Leu-Arg-Pro-Gly-NH.sub.2 in which X is D-Nal(1), D-Trp, D-Phe, D-Tyr, D-Lys, D-Met, D-Ala or D-Pgl and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
24 words
A compound of the formula: D-p-Glu-D-Phe-D-Nal(1)-Ser-Tyr-X-Leu-Arg-Pro-Gly-NH.sub.2 in which X is D-Nal(1), D-Trp, D-Phe, D-Tyr, D-Lys, D-Met, D-Ala or D-Pgl and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
16 words
A compound of claim 1 which is D-(5-oxoprolyl)-D- phenylalanyl-D-3-(1-naphthyl)-alanyl-L-seryl-L-tyrosyl-D-3-(1-naphthyl)-alanyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)-alanyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)-alanyl-L-seryl-L-tyrosyl-D-phenylalanyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)alanyl-L-seryl-L-tyrosyl-D-tyrosyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)alanyl-L-seryl-L-tyrosyl-D-lysyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)alanyl-L-seryl-L-tyrosyl-D-methionyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)-alanyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
15 words
A compound of claim 1 which is D-(5-oxoprolyl-D-phenylalanyl-D-3-(1-naphthyl)alanyl-L-seryl-L-tyrosyl-D-phenyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycine amide or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
55 words
A compound of the formula: (R)D-p-Glu-D-Phe-D-Nal(1)-Ser(R.sup.4)-Tyr(R.sup.5)-X-Leu-Arg(R.sup.8)-Pro-Gly-Z in which R is hydrogen or an alpha amino protecting group; R 4 is a hydroxyl protecting group; R 5 is a phenolic hydroxy protecting group; R 8 is a nitrogen protecting group for the guanyl side chain of arginine; and Z is a benzhydrylamine modified polystyrene resin support.
Claim 12
Dependent Claim
55 words
A compound of the formula: (R)D-p-Glu-D-Phe-D-Nal(1)-Ser(R.sup.4)-Tyr(R.sup.5)-X-Leu-Arg(R.sup.8)-Pro-Gly-Z in which R is hydrogen or an alpha amino protecting group; R 4 is a hydroxyl protecting group; R 5 is a phenolic hydroxy protecting group; R 8 is a nitrogen protecting group for the guanyl side chain of arginine; and Z is a benzhydrylamine modified polystyrene resin support.
Claim 13
Dependent Claim
11 words
The compound of claim 10 which is N-benzyloxycarbonyl-D-(5-oxoprolyl)-D-phenylalanyl-D-3-(1-naphthyl)alanyl-O-benzyl-L-seryl-O-2,6-dichlorobenzyl-L-tyrosyl-D-3-(1-naphthyl)alanyl-L-leucyl-N g -tosyl-L-arginyl-L-prolyl-glycyl-benzhydrylamine polystyrene.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-02 | 1984-09-01 | 1985-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-02 | 1988-09-01 | 1989-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-02 | 1992-09-01 | 1993-03-03 | $7700.00 | Window Closed / Lapsed |