Substituted N-iminomethylpiperidines

Claim 1

A member selected from the group consisting of a substituted N-iminomethylpiperidine of formula (I): ##STR38## and the corresponding non-toxic acid addition salts thereof, wherein: R 1 taken individually is a member selected from the group consisting of hydrogen; phenyl; phenyl substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hydroxy and halo; phenyl(C 1 -C 4 )loweralkyl; 1-phenyl(C 7 -C 9 )loweralkyl; phenyl(C 1 -C 4 ) loweralkyl and 1-phenyl(C 7 -C 9 )loweralkyl in which said phenyl is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hyroxy, halo, and phenyl, provided that no more than one member is phenyl; diphenyl(C 1 -C 4 )loweralkyl; diphenyl(C 1 -C 4 )loweralkyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, halo, hydroxy, and phenyl, provided that no more than one member is phenyl; diphenylhydroxymethyl; diphenylhydroxymethyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hydroxy, halo, and phenyl, provided that no more than one member is phenyl; and radicals of formulae: ##STR39## wherein n is 0, 1, or 2 and E is H or OH; A taken individually is a member selected from hydrogen, acetyl, and phenyl, provided that when A is acetyl or phenyl, R 1 is a member selected from the group consisting of phenyl of phenyl substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hydroxy and halo; R 1 and A taken together is a member selected from the group consisting of benzhydrylidene and radicals of formulae: ##STR40## wherein n is 0, 1, or 2; R 1 ' taken individually is a member selected from the group consisting of hydrogen; methyl; diphenylmethyl; diphenylmethyl wherein at least one of the phenyl groups is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hydroxy, halo; and phenyl, provided that no more than one member is phenyl; diphenylhydroxymethy; diphenylhydroxymethyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, halo, hydroxy, and phenyl, provided that no more than one member is phenyl; and a radical of formula: ##STR41## wherein n is 0, 1, or 2 and E is H or OH; B taken individually is hydrogen; R 1 ' and B taken together is a member selected from the group consisting of benzhydrylidene and a radical of formula ##STR42## wherein n is 0, 1, or 2 R 1 " taken individually is a member selected from the group consisting of hydrogen, diphenylmethyl; diphenylmethyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisiting of loweralkyl, loweralkoxy, halo, hydroxy, and phenyl, provided that no more than one member is phenyl; diphenylhydroxymethyl: diphenylhydroxymethyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, hydroxy, halo, and phenyl, provided that no more than one member is phenyl; and radicals of formulae: ##STR43## wherein n is 0, 1, or 2; D taken individually is hydrogen; R 1 " and D taken together is benzhydrylidene; R 2 is a member selected from the group consisting of hydrogen and C 1 -C 4 loweralkyl; and R 3 is a member selected from the group consisting of hydrogen; alkyl; cycloalkyl; phenylloweralkyl; phenylloweralkyl in which said phenyl is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkyl, hydroxy, and halo; diphenyl (C 1 -C 4 ) loweralkyl; diphenyl(C 1 -C 4 ) loweralkyl wherein at least one of said phenyls is substituted with from one to three members each selected from the group consisting of loweralkyl, loweralkoxy, halo, hydroxy, and phenyl, provided that no more than one member is phenyl; alkenyl; and alkynyl; provided that at least one of said R 1 , R 1 ', and R 1 " is other than hydrogen and further provided that when R 1 " is other than hydrogen R 1 , R 1 ', and A are each hydrogen; when R 1 ' is hydrogen only one of R 1 and R 1 " is other than hydrogen; when R 1 ' is methyl R 1 is other than hydrogen and R 1 " is hydrogen; and when R 1 ' is other than hydrogen or methyl R 1 , R 1 " and A are each hydrogen.