US4251516A
Expired / Lapsed
US
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2-Deoxy-3-O-Demethylfortimicins
Assignee: Abbott Laboratories
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Filing: 1979-09-26
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Granted: 1981-02-17
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Expires: 1999-09-26
Abstract
Abstract The present invention provides 2-deoxy-3-O-demethyl-fortimcins A and B and the 4-N-acyl and alkyl derivatives thereof, represented by the formula: ##STR1## wherein R is selected from the group consisting of hydrogen, acyl, aminoacyl,diaminoacyl,N-monoloweralkylaminoalkyl,N,N-diloweralkylaminoalkyl, hydroxy-substituted aminoacyl,loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl and hydroxy-substituted aminoloweralkyl and the pharmaceutically acceptable salts thereof.
Inventors
- 👤 Jerry R. Martin
- 👤 John S. Tadanier
- 👤 Paulette Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:15
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/224; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
45 words
A 2-deoxy-3-O-demethylfortimicin A and B and 2-deoxy-3-O-demethyl-4-N-fortimicin B derivatives represented by the formula: ##STR4## wherein R is selected from the group consisting of hydrogen, acyl, aminoacyl, diaminoacyl, N-mono loweralkylaminoalkyl, N,N-diloweralkylaminoalkyl, hydroxy-substituted aminoacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl and hydroxy-substituted aminoloweralkyl and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
45 words
A 2-deoxy-3-O-demethylfortimicin A and B and 2-deoxy-3-O-demethyl-4-N-fortimicin B derivatives represented by the formula: ##STR4## wherein R is selected from the group consisting of hydrogen, acyl, aminoacyl, diaminoacyl, N-mono loweralkylaminoalkyl, N,N-diloweralkylaminoalkyl, hydroxy-substituted aminoacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl and hydroxy-substituted aminoloweralkyl and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
17 words
A compound of claim 1 wherein R is hydrogen:2-deoxy 3-O-demethyl-fortimicin B or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
9 words
A compound of claim 1 wherein R is acyl.
Claim 5
Dependent Claim
9 words
A compound of claim 3 wherein R is aminoacyl.
Claim 6
Dependent Claim
17 words
A compound of claim 4 wherein R is glycyl: 2-deoxy-3-O-demethylfortimicin A or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
8 words
A compound of claim 5: 2-deoxy-3-O-demethylfortimicin A tetrahydrochloride.
Claim 8
Dependent Claim
8 words
A compound of claim 5: 2-deoxy-3-O-demethylfortimicin A disulfate.
Claim 9
Dependent Claim
16 words
A compound of claim 1 wherein R is 2-deoxy-3-O-demethyl-4-N-sarcosylfortimicin B or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
8 words
A compound of claim 8: 2-deoxy-3-O-demethyl-4-N-sarcosylfortimicin B tetrahydrochloride.
Claim 11
Dependent Claim
16 words
A compound of claim 1 wherein R is 2-deoxy-3-O-demethyl-4-N-β-alanylfortimicin B or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
8 words
A compound of claim 10: 2-deoxy-3-O-demethyl-4-N-β-alanylfortimicin B tetrahydrochloride.
Claim 13
Dependent Claim
19 words
A compound of claim 1 where in R is aminoalkyl: 2-deoxy-3-O-demethyl 4-N-(β-aminoethyl)fortimicin B or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
8 words
A compound of claim 12: 2-deoxy-3-O-demethyl-4-N-(β-aminoethyl)fortimicin B pentahydrochloride.
Claim 15
Dependent Claim
22 words
A pharmaceutical antibiotic composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.
Claim 16
Dependent Claim
17 words
A composition of claim 14 wherein said compound is 2-deoxy-3-O-demethylfortimicin A or a pharmaceitically acceptable salt thereof.
Claim 17
Dependent Claim
17 words
A composition of claim 14 wherein said compound is 2-deoxy-3-O-demethyl-4-N-sarcosylfortimicin B or a pharmaceutically acceptable salt thereof.
Claim 18
Dependent Claim
17 words
A composition of claim 14 wherein said compound is 2-deoxy-3-O-demethyl-4-N-β-alanylfortimicin B or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim
16 words
A composition of claim 14 wherein said compound is 2-deoxy-3-O-demethyl-4-N-(β-aminoethyl)fortimicin B or pharmaceutically acceptable salt thereof.
Claim 20
Dependent Claim
30 words
A method of treating a patient suffering from an infection caused by a susceptible organism comprising administering a therapeutically effective amount of a compound of claim 1 to said patient.
References Cited (Backward Citations)
US4124756A
Cited
US4169198A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-17 | 1984-08-18 | 1985-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-17 | 1988-08-18 | 1989-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-17 | 1992-08-18 | 1993-02-17 | $7700.00 | Window Closed / Lapsed |