US4250186A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of slowing heart rate
Assignee: Boehringer Ingelheim GmbH
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Filing: 1979-02-16
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Granted: 1981-02-10
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Expires: 1999-02-16
Abstract
Abstract Compounds of the formula <IMAGE> wherein R is 2-bromo-4,5-dihydroxy-phenyl; 3-chloro-4-hydroxy-phenyl; 4-bromo-2,5-dihydroxy-phenyl; 3,5-dihydroxy-phenyl; 5-chloro-2,4-dihydroxy-phenyl; 3-hydroxy-4-methyl-phenyl; 2,6-dibromo-4-hydroxymethyl-phenyl; 3,5-dibromo-4-amino-phenyl; 3-methylmercapto-phenyl; 3,4,5-trihydroxy-phenyl; or 3-bromo-4-fluoro-phenyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Wolfgang Hoefke
- 👤 Wolfram Gaida
- 👤 Ludwig Pichler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:44
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50; A; A61; A61P; A61P9/00; A61P9/06; A61P9/10
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
58 words
The method of slowing the heart rate of a warm-blooded animal in need thereof, which comprises enterally or parenterally administering to said animal an effective bradycardiac amount of a compound of the formula ##STR7## wherein R is 2-bromo-4,5-dihydroxy-phenyl; 3-chloro-4-hydroxy-phenyl; 4-bromo-2,5-dihydroxy-phenyl; 3,5-dihydroxy-phenyl; 5-chloro-2,4-dihyroxyphenyl; 3-hydroxy-4-methyl-phenyl; 2,6-dibromo-4-hydroxy-methyl-phenyl; 3,5-dibromo-4-amino-phenyl; 3-methyl-mercapto-phenyl; 3,4,5-trihydroxy-phenyl; or 3-bromo-4-fluoro-phenyl; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Independent Claim
58 words
The method of slowing the heart rate of a warm-blooded animal in need thereof, which comprises enterally or parenterally administering to said animal an effective bradycardiac amount of a compound of the formula ##STR7## wherein R is 2-bromo-4,5-dihydroxy-phenyl; 3-chloro-4-hydroxy-phenyl; 4-bromo-2,5-dihydroxy-phenyl; 3,5-dihydroxy-phenyl; 5-chloro-2,4-dihyroxyphenyl; 3-hydroxy-4-methyl-phenyl; 2,6-dibromo-4-hydroxy-methyl-phenyl; 3,5-dibromo-4-amino-phenyl; 3-methyl-mercapto-phenyl; 3,4,5-trihydroxy-phenyl; or 3-bromo-4-fluoro-phenyl; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-10 | 1984-08-11 | 1985-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-10 | 1988-08-11 | 1989-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-10 | 1992-08-11 | 1993-02-10 | $7700.00 | Window Closed / Lapsed |