US4248840A
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Cis-diammineplatinum(II) orthophosphate complexes
Assignee: BASF Catalysts LLC
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Filing: 1979-03-07
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Granted: 1981-02-03
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Expires: 1999-03-07
Abstract
Abstract Cis-diammineplatinum(II) orthophosphate complexes are prepared by reaction of diaquo-cis-diammineplatinum(II) salts with alkali metal orthophosphates. The resulting complexes possess pronounced anti-tumor activity in mice and low toxicity; consequently, they have high therapeutic indices.
Inventors
- 👤 James D. Hoeschele
- 👤 Alan R. Amundsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:52
CPC Classifications
C; C01; C01B; C01B21/00; C01B21/082; C01B21/097; A; A61; A61K; A61K33/00; A61K33/42; A61P; A61P35/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
45 words
A cis-diammineplatinum(II) orthophosphate complex comprising the cis-diammineplatinum moiety cis-{Pt(NH 3 ) 2 } and an orthophosphate moiety of the formula (H 2-n PO 4 ) - (1+n), wherein the atomic ratio of phosphorous to platinum is about 0.5 to 1 or about 1 to 1.
Claim 2
Dependent Claim
45 words
A cis-diammineplatinum(II) orthophosphate complex comprising the cis-diammineplatinum moiety cis-{Pt(NH 3 ) 2 } and an orthophosphate moiety of the formula (H 2-n PO 4 ) - (1+n), wherein the atomic ratio of phosphorous to platinum is about 0.5 to 1 or about 1 to 1.
Claim 3
Dependent Claim
24 words
A yellow complex according to claim 1 having the empirical formula cis-[Pt(NH 3 ) 2 (OH)] 2 (H 2 PO 4 ) 2 .
Claim 4
Dependent Claim
24 words
A complex according to claim 1 having the empirical formula cis-{Pt(NH 3 ) 2 } 2 (HPO 4 ) (OH) 2 (H 2 O).
Claim 5
Dependent Claim
3 words
Hydrated cis-diammineplatinum(II) orthophosphate.
Claim 6
Dependent Claim
3 words
Hydrated cis-diammineplatinum(II) orthophosphate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-03 | 1984-08-04 | 1985-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-03 | 1988-08-04 | 1989-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-03 | 1992-08-04 | 1993-02-03 | $7700.00 | Window Closed / Lapsed |