US4248786A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxy-succinimide ester compounds
Assignee: Roche Diagnostics GmbH
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Filing: 1979-03-08
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Granted: 1981-02-03
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Expires: 1999-03-08
Abstract
Abstract New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is -O-CH 2 -CH 2 when n is 2 and X is a succinimide ester group but otherwise is a single bond; n is a whole number of from 2 to 7; m is 1, 2, 3 or 4, R is hydrogen, methyl, or cyanide; and R' is methyl or ethyl. have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.
Inventors
- 👤 Hans-Georg Batz
- 👤 Jurgen Horn
- 👤 Klaus Stellner
- 👤 Josef Maier
- 👤 Michael Nelboeck-Hochstetter
- 👤 Gunter Weimann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:06
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/46; C08; C08F; C08F20/00; C08F20/02; C08F20/10; C08F20/34; C08F20/36
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
47 words
Hydroxy-succinimide ester compound of the formula ##STR5## wherein X is a carboxy-succinimide ester group A is --O--CH 2 --CH 2 when n is 2 but otherwise is a single bond; n is a whole number of from 2 to 7; m is 1, 2, 3 or 4.
Claim 2
Dependent Claim
47 words
Hydroxy-succinimide ester compound of the formula ##STR5## wherein X is a carboxy-succinimide ester group A is --O--CH 2 --CH 2 when n is 2 but otherwise is a single bond; n is a whole number of from 2 to 7; m is 1, 2, 3 or 4.
Claim 3
Dependent Claim
20 words
Hydroxy-succinimide ester compound as claimed in claim 1 wherein A is --O--CH 2 --CH 2 , and n is 2.
Claim 4
Dependent Claim
21 words
Hydroxy-succinimide ester compound as claimed in claim 1 wherein A is a single bond and n is from 3 to 7.
Claim 5
Dependent Claim
15 words
Hydroxy-succinimide ester compound as claimed in claim 1 designated ethylene glycol bis-propionic acid bis-hydroxy-succinimide ester.
Claim 6
Dependent Claim
13 words
Hydroxy-succinimide ester compound as claimed in claim 1 designated oxy-bis-propionic acid hydroxy-succinimide ester.
References Cited (Backward Citations)
US3978079A
Cited
US3940420A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-02-03 | 1984-08-04 | 1985-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-02-03 | 1988-08-04 | 1989-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-02-03 | 1992-08-04 | 1993-02-03 | $7700.00 | Window Closed / Lapsed |