US4247292A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Natural tissue heart valve fixation process
Assignee: Individual
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Filing: 1979-06-06
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Granted: 1981-01-27
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Expires: 1999-06-06
Abstract
Abstract A process for fixing a natural tissue heart valve whereby the valve has improved hydraulic performance is disclosed. The valve is first placed in glutaraldehyde with the valve cusps kept in the closed position by applying hydraulic pressure to the ventricular side of the valve. The valve is then trimmed and fitted to and sutured into a fabric covered plastic stent. An expandable tube is then placed axially within the valve and expanded to force the valve cusps into an open position. The expanded tube-valve-stent assembly is then placed in glutaraldehyde to further fix the valve and predispose the valve cusps to an open position.
Inventors
- 👤 William W. Angell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:02
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61F2/2415; A61L27/36; A61L27/3604; A61L27/3625; A61L27/3641; A61L27/3683; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
79 words
Process for fixing a natural tissue heart valve prosthesis comprising: (a) contacting the valve with a fixing agent with the valve cusps in a closed position so as to partially fix the valve such that the configuration and dimensions of the valve are substantially set; and (b) thereafter contacting the valve with the fixing agent with the valve cusps in an open position whereby the valve is further fixed and the valve cusps are predisposed to an open position.
Claim 2
Dependent Claim
79 words
Process for fixing a natural tissue heart valve prosthesis comprising: (a) contacting the valve with a fixing agent with the valve cusps in a closed position so as to partially fix the valve such that the configuration and dimensions of the valve are substantially set; and (b) thereafter contacting the valve with the fixing agent with the valve cusps in an open position whereby the valve is further fixed and the valve cusps are predisposed to an open position.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein the valve is a porcine valve.
Claim 4
Dependent Claim
15 words
The process of claim 2 wherein the fixing agent is an aqueous solution of glutaraldehyde.
Claim 5
Dependent Claim
17 words
The process of claim 3 wherein the glutaraldehyde concentration in the solution is 0.5 % by weight.
Claim 6
Dependent Claim
37 words
The process of claim 4 wherein in step (a) the valve is contacted with the glutaraldehyde solution for about four hours and in step (b) the valve is contacted with the glutaraldehyde solution for about four hours.
Claim 7
Dependent Claim
26 words
The process of claim 1 wherein the valve is packed with a packing material to hold the valve cusps in a closed position in step (a).
Claim 8
Dependent Claim
28 words
The process of claim 1 wherein hydraulic pressure is applied to ventricular side of the valve to hold the valve cusps in a closed position in step (a).
Claim 9
Dependent Claim
21 words
The process of claim 1 wherein the valve is fitted to and affixed within a stent between steps (a) and (b).
Claim 10
Dependent Claim
30 words
The process of claim 1 wherein an expandable member is placed axially within the valve and expanded therein to hold the valve cusps in an open position in step (b).
Claim 11
Dependent Claim
93 words
Process for fixing a porcine heart valve prosthesis comprising: (a) contacting the valve with an aqueous solution of glutaraldehyde with the valve cusps in a closed position for a time sufficient to partially fix the valve and substantially set the configuration and dimensions of the valve; (b) fitting and affixing the valve within a stent; and (c) contacting the valve-stent assembly with an aqueous solution of glutaraldehyde with the valve cusps in an open position for a time sufficient to further fix the valve and predispose the valve cusps to an open position.
Claim 12
Dependent Claim
93 words
Process for fixing a porcine heart valve prosthesis comprising: (a) contacting the valve with an aqueous solution of glutaraldehyde with the valve cusps in a closed position for a time sufficient to partially fix the valve and substantially set the configuration and dimensions of the valve; (b) fitting and affixing the valve within a stent; and (c) contacting the valve-stent assembly with an aqueous solution of glutaraldehyde with the valve cusps in an open position for a time sufficient to further fix the valve and predispose the valve cusps to an open position.
Claim 13
Dependent Claim
54 words
The process of claim 10 wherein hydraulic pressure is applied to the ventricular side of the valve to hold the valve cusps in a closed position in step (a) and an expandable member is placed axially within the valve and expanded therein to hold the valve cusps in an open position in step (c).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-27 | 1984-07-28 | 1985-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-27 | 1988-07-28 | 1989-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-27 | 1992-07-28 | 1993-01-27 | $7700.00 | Window Closed / Lapsed |