US4246282A
Expired / Lapsed
US
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ω-Dialkylalkanoic acid derivatives used to induce antianoxic activity
Assignee: Sanofi Aventis France
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Filing: 1979-06-07
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Granted: 1981-01-20
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Expires: 1999-06-07
Abstract
Abstract omega -Dialkylalkanoic acid derivatives of the formula: <IMAGE> in which R1 and R2, which can be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms and n represents 0, 1, 2 or 3. They possess a competitive inhibitory activity with respect to gamma -aminobutyric alpha -ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders, whether resulting or not from cerebral ischemia, and disorders relating to the field of neuropsychiatry.
Inventors
- 👤 Michel Chignac
- 👤 Claude Grain
- 👤 Fernand Jammot
- 👤 Charles Pigerol
- 👤 Pierre L. Eymard
- 👤 Madeleine Combet (epse Broll)
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:46
CPC Classifications
C; C07; C07C; C07C255/00; A; A61; A61K; A61K31/00; A61K31/16; C07C29/00; C07C29/132; C07C29/136; C07C29/147
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
57 words
A method for inducing an antianoxic action in a host in need of such treatment, comprising the administration to said host of an ω-dialkylalkanoic acid derivative of general formula: ##STR15## in which n represents 0, 1 or 2, at a daily dosage between 200 and 1500 milligrams of ω-dialkylakanoic acid derivative per 60 kilograms of body weight.
Claim 2
Independent Claim
57 words
A method for inducing an antianoxic action in a host in need of such treatment, comprising the administration to said host of an ω-dialkylalkanoic acid derivative of general formula: ##STR15## in which n represents 0, 1 or 2, at a daily dosage between 200 and 1500 milligrams of ω-dialkylakanoic acid derivative per 60 kilograms of body weight.
Claim 3
Dependent Claim
8 words
Method of claim 1 wherein n is 2.
Claim 4
Dependent Claim
26 words
Method of claims 1 or 2 wherein the human dosage of the ω-dialkylalkanoic acid derivative is between 200 and 1500 milligrams per 60 kilograms per day.
Claim 5
Dependent Claim
52 words
A pharmaceutical or veterinary composition having an antianoxic action comprising as an essential active ingredient an ω-dialkylalkanoic acid derivative of general formula: ##STR16## in which n represents 0, 1 or 2, in association with a pharmaceutical carrier, in dosage unit form containing from 50 to 600 milligrams of active ingredients per unit.
Claim 6
Dependent Claim
52 words
A pharmaceutical or veterinary composition having an antianoxic action comprising as an essential active ingredient an ω-dialkylalkanoic acid derivative of general formula: ##STR16## in which n represents 0, 1 or 2, in association with a pharmaceutical carrier, in dosage unit form containing from 50 to 600 milligrams of active ingredients per unit.
References Cited (Backward Citations)
GB760114A
Cited
US3988472A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-20 | 1984-07-21 | 1985-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-20 | 1988-07-21 | 1989-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-20 | 1992-07-21 | 1993-01-20 | $7700.00 | Window Closed / Lapsed |