Compositions and methods for reducing elution of therapeutic agents from teeth

Claim 1

A dentifrice composition for substantially effectively coating previously fluoride-treated teeth and thereby reducing elution of said fluoride from said teeth, said composition comprising a fluoride-containing caries prophylactic agent provided that said agent is substantially free from polyvalent metal atoms; and at least about 0.05% by weight of an anionic, water-dispersible, membrane-forming material which, when applied to the surface of said previously fluoride-treated teeth in an oral environment, complexes with the calcium of said teeth and forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied fluoride from said teeth, and which, when at equilibrium with the complex, has a formation constant in the range of about 0.5 to 8, said membrane-forming material having the formula R.sub.f SO.sub.2 N(R.sup.2)R.sup.3 COOM wherein R f is a monovalent, stable, inert, fluorinated, saturated, non-polar radical containing from about 4 to 16 carbon atoms; R 2 is selected from hydrogen and alkyl groups containing from about 2 to 3 carbon atoms; R 3 is selected from alkylene and alkarylene groups that contain from about 1 to 10 carbon atoms; and M is selected from hydrogen, alkali metal, ammonium, and amine groups.

Claim 7

A method of substantially reducing elution of a therapeutic agent previously applied to teeth which comprises the steps of applying said therapeutic agent to teeth, and applying a dentifrice composition to said treated teeth, wherein said dentifrice composition comprises (1) at least one ingredient selected from the group consisting of therapeutic agents, polishing agents, surfactants, flavoring agents, sweetening agents, thickening agents and humectants that are substantially free from polyvalent metal atoms, and (2) at least 0.05% by weight of an anionic, water-dispersible, membrane-forming material which, when applied to the surface of the teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied therapeutic agent from said teeth, and which, when at equilibrium with the complex has a formation constant in the range of about 0.5 to 8, wherein said membrane-forming material has the formula R f SO 2 N(R 2 )R 3 COOM wherein R f is a monovalent, stable, inert, fluorinated, saturated, non-polar radical containing from about 4 to 16 carbon atoms; R 2 is selected from hydrogen and alkyl groups containing from about 2 to 3 carbon atoms; R 3 is selected from alkylene and alkarylene groups that contain from about 1 to 10 carbon atoms; and M is selected from hydrogen, alkali metal, ammonium and amine groups, and allowing said hydrophobic barrier to form on said teeth.

Claim 8

A method of substantially reducing elution of a therapeutic agent previously applied to teeth which comprises the steps of applying said therapeutic agent to teeth, and applying a dentifrice composition to said treated teeth, wherein said dentifrice composition comprises (1) at least one ingredient selected from the group consisting of therapeutic agents, polishing agents, surfactants, flavoring agents, sweetening agents, thickening agents and humectants that are substantially free from polyvalent metal atoms, and (2) at least 0.05% by weight of an anionic, water-dispersible, membrane-forming material which, when applied to the surface of the teeth in an oral environment, forms a substantially continuous hydrophobic barrier thereon which substantially reduces the elution of said previously applied therapeutic agent from said teeth, and which, when at equilibrium with the complex has a formation constant in the range of about 0.5 to 8, wherein said membrane-forming material has the formula R f SO 2 N(R 2 )R 3 COOM wherein R f is a monovalent, stable, inert, fluorinated, saturated, non-polar radical containing from about 4 to 16 carbon atoms; R 2 is selected from hydrogen and alkyl groups containing from about 2 to 3 carbon atoms; R 3 is selected from alkylene and alkarylene groups that contain from about 1 to 10 carbon atoms; and M is selected from hydrogen, alkali metal, ammonium and amine groups, and allowing said hydrophobic barrier to form on said teeth.