US4243605A
Expired / Lapsed
US
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Novel isocyanates
Assignee: Adaltis US Inc
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Filing: 1978-07-03
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Granted: 1981-01-06
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Expires: 1998-07-03
Abstract
Abstract Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form derivatives receptive to tagging, as by radioliabeling. The tagged derivatives may then be employed to determine the presence of the compound of interest in nanomolar or even picomolar amounts by using clinical analysis techniques such as radioimmunoassay.
Inventors
- 👤 William A. Eisenhardt, Jr.
- 👤 Eddie Hedaya
- 👤 Spyros Theodoropulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 13:43
CPC Classifications
C; C07; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07J; C07J41/00; C07J41/0033; C07J41/0055; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/534
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
46 words
Isocyanates having the structural formaula: (R).sub.3 SiO--R'--N═C═O wherein R is a member selected from the group consisting of lower alkyl, alicyclics, aryl, alkaryl and aralkyl, each having no more than about 10 carbon atoms and R' is a radical selected from the group consisting of ##STR23##
Claim 2
Dependent Claim
46 words
Isocyanates having the structural formaula: (R).sub.3 SiO--R'--N═C═O wherein R is a member selected from the group consisting of lower alkyl, alicyclics, aryl, alkaryl and aralkyl, each having no more than about 10 carbon atoms and R' is a radical selected from the group consisting of ##STR23##
Claim 3
Dependent Claim
9 words
The isocyanates of claim 1 wherein R' is ##STR24##
Claim 4
Dependent Claim
9 words
The isocyanates of claim 1 wherein R' is ##STR25##
Claim 5
Dependent Claim
13 words
The isocyanates of claim 1 wherein R' is --(CH 2 ) 2 --.
References Cited (Backward Citations)
US4031121A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-06 | 1984-07-07 | 1985-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-06 | 1988-07-07 | 1989-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-06 | 1992-07-07 | 1993-01-06 | $7700.00 | Window Closed / Lapsed |