US4242329A
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Bradykinin-inhibiting tripeptide derivatives
Assignee: Phadia AB
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Filing: 1979-07-17
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Granted: 1980-12-30
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Expires: 1999-07-17
Abstract
Abstract Tripeptide derivatives of the formula H-D-X-Phe-Arg-Y in which X is selected from the group consisting of Pro and Phe Y is selected from the group consisting of O--R 1 and NH--R 2 in which R 1 is selected from the group consisting of straight, branched and cyclic alkyl group with 1-12 C atoms, and R 2 is selected from the group consisting of H, straight, branched and cyclic alkyl group with 1-12 C atoms, and physiologically acceptable salts thereof. A process for producing said tripeptide derivatives by synthesis and purification methods which are known in the peptide chemistry. Pharmaceutical preparations comprising said tripeptide derivatives.
Inventors
- 👤 Karl G. Claeson
- 👤 Leif R. Simonsson
- 👤 Salo Arielly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:19
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/0823; C07K5/0802; C07K5/0812
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
79 words
Tripeptide derivatives of the formula H-D-X-Phe-Arg-Y in which X is selected from the group consisting of Pro and Phe Y is selected from the group consisting of O--R 1 and NH--R 2 in which R 1 is selected from the group consisting of straight, branched and cyclic alkyl group with 1-12 C atoms, and R 2 is selected from the group consisting of H, straight, branched and cyclic alkyl group with 1-12 C atoms, and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
79 words
Tripeptide derivatives of the formula H-D-X-Phe-Arg-Y in which X is selected from the group consisting of Pro and Phe Y is selected from the group consisting of O--R 1 and NH--R 2 in which R 1 is selected from the group consisting of straight, branched and cyclic alkyl group with 1-12 C atoms, and R 2 is selected from the group consisting of H, straight, branched and cyclic alkyl group with 1-12 C atoms, and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
10 words
The tripeptide derivative of claim 1 wherein X is Pro.
Claim 4
Dependent Claim
10 words
The tripeptide derivative of claim 4 wherein Y is O--R.
Claim 5
Dependent Claim
10 words
The tripeptide derivative of claim 1 wherein Y is O--R.
Claim 6
Dependent Claim
10 words
The tripeptide derivative of claim 1 wherein Y is O-heptyl.
Claim 7
Dependent Claim
12 words
The tripeptide derivative of claim 2 wherein Y is NHR 2 .
Claim 8
Dependent Claim
12 words
The tripeptide derivative of claim 1 wherein Y is NHR 2 .
Claim 9
Dependent Claim
11 words
The tripeptide derivative of claim 1 wherein Y is NH heptyl.
Claim 10
Dependent Claim
12 words
The tripeptide derivative of claim 1 wherein Y is NH 2 .
Claim 11
Dependent Claim
10 words
The tripeptide derivative of claim 1 wherein Y is O-isopropyl.
Claim 12
Dependent Claim
10 words
The tripeptide derivative of claim 1 wherein X is Phe.
Claim 13
Dependent Claim
11 words
The tripeptide derivative of claim 1 wherein Y is NH lauryl.
Claim 14
Dependent Claim
11 words
The tripeptide derivative of claim 1 wherein Y is NH cyclohexyl.
Claim 15
Dependent Claim
14 words
The tripeptide derivative of claim 1 wherein X is Pro and Y is O-heptyl.
Claim 16
Dependent Claim
14 words
The tripeptide derivative of claim 1 wherein X is Pro and Y is NH-heptyl.
Claim 17
Dependent Claim
16 words
The tripeptide derivative of claim 1 wherein X is Pro and Y is NH 2 .
Claim 18
Dependent Claim
14 words
The tripeptide derivative of claim 1 wherein X is Pro and Y is O-isopropyl.
Claim 19
Dependent Claim
16 words
The tripeptide derivative of claim 1 wherein X is Phe and Y is NH 2 .
Claim 20
Dependent Claim
15 words
The tripeptide derivative of claim 1 wherein X is Phe and Y is NH heptyl.
Claim 21
Dependent Claim
15 words
The tripeptide derivative of claim 1 wherein X is Pro and Y is NH lauryl.
Claim 22
Dependent Claim
15 words
The tripeptide derivative of claim 1 wherein X is Phe and Y is NH isopropyl.
Claim 23
Dependent Claim
15 words
The tripeptide derivative of claim 1 wherein X is Phe and Y is NH cyclohexyl.
Claim 24
Dependent Claim
25 words
Pharmaceutical preparation for the inhibition of bradykinin which comprises the tripeptide derivative of claim 1 in an amount sufficient to inhibit the formation of bradykinin.
Claim 25
Dependent Claim
20 words
A process for inhibiting the formation of bradykinin which comprises administering to a host the pharmaceutical preparation of claim 23.
References Cited (Backward Citations)
US4110322A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-30 | 1984-06-30 | 1984-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-30 | 1988-06-30 | 1988-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-30 | 1992-06-30 | 1992-12-30 | $7700.00 | Window Closed / Lapsed |