US4239761A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Basically substituted ureas and processes for the treatment of virus diseases
Assignee: Asta Medica GmbH
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Filing: 1979-08-23
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Granted: 1980-12-16
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Expires: 1999-08-23
Abstract
Abstract The present invention is related to new basically substituted ureas having the general Formula I <IMAGE> I and the pharmaceutically acceptable acid addition salts thereof which produce an improved antiviral activity against DNS- and RNS-viruses. The invention is further related to the treatment of humans or animals suffering from diseases caused by viruses by administering compositions containing such ureas or salts thereof as active agent.
Inventors
- 👤 Rolf Rebling
- 👤 Gerhard Scheffler
- 👤 Klaus Pressler
- 👤 Klaus D. Schenk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:09
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/215; A; A61; A61P; A61P1/00; A61P11/00; A61P25/00; A61P31/00; A61P31/12; C07D295/04; C07D295/12; C07D295/125; C07D295/13; C07D295/22; C07D295/26
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
9 words
Basically substituted ureas of the general Formula I ##STR24##
Claim 2
Dependent Claim
9 words
Basically substituted ureas of the general Formula I ##STR24##
Claim 3
Dependent Claim
83 words
wherein X is the group R 4 --N<, p is 2 or 3, R 1 is an alkyl group having from 6 to 18 carbon atoms, R 2 and R 3 , which may be the same or different from each other, are methyl or ethyl and R 4 is the methyl sulfonyl group, the diethyl carbamoyl group or the group ##STR25## wherein q is 1 or 2 and R 8 is methyl, methoxy, chlorine or bromine, and the pharmacologically acceptable salts thereof.
Claim 4
Dependent Claim
83 words
wherein X is the group R 4 --N<, p is 2 or 3, R 1 is an alkyl group having from 6 to 18 carbon atoms, R 2 and R 3 , which may be the same or different from each other, are methyl or ethyl and R 4 is the methyl sulfonyl group, the diethyl carbamoyl group or the group ##STR25## wherein q is 1 or 2 and R 8 is methyl, methoxy, chlorine or bromine, and the pharmacologically acceptable salts thereof.
Claim 5
Dependent Claim
8 words
N,N'-Dimethyl-N-n-tetradecyl-N'-[2-(1-diethylcarbamoyl-4-piperazinyl)-ethyl]-urea and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
8 words
N,N'-Dimethyl-N-n-tetradecyl-N'-[2-(1-diethylcarbamoyl-4-piperazinyl)-ethyl]-urea and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
8 words
N,N'-Dimethyl-N-n-tetradecyl-N'-{2-[1-(2-p-toluyl-ethyl)-4-piperazinyl]-ethyl}-urea and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
8 words
N,N'-Dimethyl-N-n-tetradecyl-N'-{2-[1-(2-p-toluyl-ethyl)-4-piperazinyl]-ethyl}-urea and its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
64 words
Process for the treatment of humans or animals suffering from a diseases caused by viruses comprising administering to said human or animal a compound according to claim 1 topically in a dose ranging from 0.005 to 0.3 percent by weight or parenterally in a daily dose ranging from 5 to 250 mg per kg body weight of the human or animal to be treated.
Claim 10
Dependent Claim
41 words
Process according to claim 4 wherein the active compound according to claim 1 is administered topically in a dose ranging from 0.01 to 0.1 percent by weight and parenterally in a daily dose ranging from 10 to 200 mg per kg.
References Cited (Backward Citations)
DE2150438C3
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-16 | 1984-06-16 | 1984-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-16 | 1988-06-16 | 1988-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-16 | 1992-06-16 | 1992-12-16 | $7700.00 | Window Closed / Lapsed |