US4237046A
Expired / Lapsed
US
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Polypeptides and methods of preparation
Assignee: The University of Texas System
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Filing: 1979-04-27
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Granted: 1980-12-02
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Expires: 1999-04-27
Abstract
Abstract There are disclosed active fragments of vasoactive peptides and methods of preparation. The active fragments comprise the following amino acid sequences: (a) X-MET-ALA-VAL-X1 (b) X-MET-ALA-VAL-LYS-X1 (c) X-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-Y-LEU-Z-X1 wherein X is hydrogen, glutamyl, or pyroglutamyl, X1 is OH or NH2; Y is ILE or VAL; and Z is ASN or THR.
Inventors
- 👤 Miklos Bodanszky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:22
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1013; C07K14/00; C07K14/435; C07K14/575; C07K14/57563; C07K5/1021; C07K5/1024; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/17
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
61 words
A new polypeptide selected from the group consisting of those of the following general formulae: (a) X-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Y-Leu-Z-X 1 wherein X is hydrogen, Gln, or pyroglutamyl; X 1 is OH or NH 2 ; Y is Val or Ile; and Z is Asn or Thr; and (b) (X) 0-1 -Met-Ala-Val-(Lys) 0-1 -X 1 wherein X and X 1 are as described above.
Claim 2
Dependent Claim
61 words
A new polypeptide selected from the group consisting of those of the following general formulae: (a) X-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Y-Leu-Z-X 1 wherein X is hydrogen, Gln, or pyroglutamyl; X 1 is OH or NH 2 ; Y is Val or Ile; and Z is Asn or Thr; and (b) (X) 0-1 -Met-Ala-Val-(Lys) 0-1 -X 1 wherein X and X 1 are as described above.
Claim 3
Dependent Claim
15 words
A polypeptide according to claim 1 wherein X is hydrogen and X 1 is OH.
Claim 4
Dependent Claim
10 words
A polypeptide according to claim 1 wherein X is pyroglutamyl.
Claim 5
Dependent Claim
16 words
A polypeptide according to claim 1 wherein X is hydrogen, X 1 is NH 2 .
Claim 6
Dependent Claim
10 words
A polypeptide according to claim 1 wherein X is Gln.
Claim 7
Dependent Claim
10 words
A polypeptide according to claim 1 wherein X is pyroglutamyl.
Claim 8
Dependent Claim
14 words
A polypeptide according to claim 1 wherein Y is Ile and Z is Asn.
Claim 9
Dependent Claim
14 words
A polypeptide according to claim 1 wherein Y is Val and Z is thr.
Claim 10
Dependent Claim
16 words
The free polypeptide and C-terminal amide of VIP 17-19 having the following amino acid sequence: Met-Ala-Val.
Claim 11
Dependent Claim
16 words
The free polypeptide and C-terminal amide of VIP 17-19 having the following amino acid sequence: Met-Ala-Val.
Claim 12
Dependent Claim
16 words
The free polypeptide and C-terminal amide of VIP 16-19 having the following amino acid sequence: Met-Ala-Val-Lys.
Claim 13
Dependent Claim
16 words
The free polypeptide and C-terminal amide of VIP 16-19 having the following amino acid sequence: Met-Ala-Val-Lys.
Claim 14
Dependent Claim
22 words
The free polypeptide, and C-terminal amide of VIP 16-20 having the following amino acid sequence: X-Met-Ala-Val-Lys wherein X is Gln or pyroglutamyl.
Claim 15
Dependent Claim
22 words
The free polypeptide, and C-terminal amide of VIP 16-20 having the following amino acid sequence: X-Met-Ala-Val-Lys wherein X is Gln or pyroglutamyl.
Claim 16
Dependent Claim
33 words
The free peptide and C-terminal amide of VIP 16-28 having the following amino acid sequence: X-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Y-Leu-Z wherein X is Gln or pyroglutamyl; Y is Val or Ile and Z is Thr or Asn.
Claim 17
Dependent Claim
33 words
The free peptide and C-terminal amide of VIP 16-28 having the following amino acid sequence: X-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Y-Leu-Z wherein X is Gln or pyroglutamyl; Y is Val or Ile and Z is Thr or Asn.
Claim 18
Dependent Claim
13 words
A polypeptide according to claim 1 of the following amino acid sequence: Met-Ala-Val.
Claim 19
Dependent Claim
13 words
A polypeptide according to claim 1 of the following amino acid sequence: Met-Ala-Val-Lys.
Claim 20
Dependent Claim
13 words
A polypeptide according to claim 1 of the following amino acid sequence: Gln-Met-Ala-Val-Lys.
Claim 21
Dependent Claim
13 words
A polypeptide according to claim 1 of the following amino acid sequence: Gln-Met-Ala-Vla-Lys-Lys-Tyr-Leu-Asn-Ser-Val-Leu-Thr.
References Cited (Backward Citations)
US3862927A
Cited
US4016258A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-02 | 1984-06-02 | 1984-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-02 | 1988-06-02 | 1988-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-02 | 1992-06-02 | 1992-12-02 | $7700.00 | Window Closed / Lapsed |