US4234566A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihistamine and methods for use thereof
Assignee: Meda Pharmaceuticals Inc
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Filing: 1979-06-29
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Granted: 1980-11-18
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Expires: 1999-06-29
Abstract
Abstract Antiperspirant compositions containing antihistamines, such as diphenhydramine hydrochloride, alone or in combination with astringent metallic salts, as the active agent effective for retarding or inhibiting perspiration when topically applied to the human skin. Method for controlling or preventing perspiration in humans.
Inventors
- 👤 Elias W. Packman
- 👤 Ruth Jeffkin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:12
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/41; A61K8/49; A61K8/4906; A61K8/4926; A61Q; A61Q15/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
85 words
An antiperspirant composition useful for prophylactic control of sweating of generally unexposed areas of the body subject to sweating in humans, comprising an antihistamine selected from the group consisting of an ehtanolamine, an ethylenediamine, an alkylamine, a phenothiazine and piperazine, or physiologically acceptable salt thereof, in conjunction with a metal salt having astringent properties and a pharmaceutically acceptable carrier, the combined amounts of antihistamine and of the metal salt act together to produce a synergistic effect and being in an amount effective to control perspiration.
Claim 2
Dependent Claim
85 words
An antiperspirant composition useful for prophylactic control of sweating of generally unexposed areas of the body subject to sweating in humans, comprising an antihistamine selected from the group consisting of an ehtanolamine, an ethylenediamine, an alkylamine, a phenothiazine and piperazine, or physiologically acceptable salt thereof, in conjunction with a metal salt having astringent properties and a pharmaceutically acceptable carrier, the combined amounts of antihistamine and of the metal salt act together to produce a synergistic effect and being in an amount effective to control perspiration.
Claim 3
Dependent Claim
10 words
The composition of claim 1 wherein the antihistamine is chlorpheniramine.
Claim 4
Dependent Claim
10 words
The composition of claim 1 wherein the antihistamine is diphenhydramine.
Claim 5
Dependent Claim
10 words
The composition of claim 1 wherein the antihistamine is triplennamine.
Claim 6
Dependent Claim
15 words
The composition of claim 1 wherein the amount of antihistamine is at least about 1%.
Claim 7
Independent Claim
83 words
The method of controlling perspiration which comprises administering topically to a human, a synergistic antiperspirant composition comprising an antihistamine selected from the group consisting of an ethanolamine, an ethylenediamine, an alkylamine, a phenothiazine and a piperazine, or a physiologically acceptable salt thereof, in conjunction with a metal salt having astringent properties, and a pharmaceutically acceptable carrier, the combined amounts of the antihistamine and the metal salt act together to produce a synergistic effect and being in an amount effective to control the perspiration.
Claim 8
Independent Claim
83 words
The method of controlling perspiration which comprises administering topically to a human, a synergistic antiperspirant composition comprising an antihistamine selected from the group consisting of an ethanolamine, an ethylenediamine, an alkylamine, a phenothiazine and a piperazine, or a physiologically acceptable salt thereof, in conjunction with a metal salt having astringent properties, and a pharmaceutically acceptable carrier, the combined amounts of the antihistamine and the metal salt act together to produce a synergistic effect and being in an amount effective to control the perspiration.
Claim 9
Dependent Claim
17 words
The method of claim 6 wherein the administration is to the axillary area of the human body.
Claim 10
Dependent Claim
38 words
The method of claim 6 wherein the administration comprises applying the composition under conditions where no sweating is occuring, then subjecting the area so treated to conditions of heat which induce sweating and inhibiting sweating under such conditions.
Claim 11
Dependent Claim
10 words
The method of claim 6 wherein the administration is prophylactic.
Claim 12
Dependent Claim
16 words
The method of claim 9 wherein the administration is to the axillary area of the body.
Claim 13
Dependent Claim
33 words
The method of claim 6 wherein the metal salt is present in said antiperspirant composition in an amount less than that which is effective to be astringent to control perspiration when used alone.
Claim 14
Dependent Claim
29 words
The method of claim 6 wherein the metal salt is present in said antiperspirant composition in a range from a small but perceptible amount to about 2% by weight.
Claim 15
Dependent Claim
29 words
The method of claim 11 wherein the metal salt is present in said antiperspirant composition in an amount in the range of about 0.1% to about 1% by weight.
Claim 16
Dependent Claim
29 words
The method in claim 6 wherein the antihistamine is present in said antiperspirant composition in an amount less than that which is effective to control perspiration when used alone.
Claim 17
Dependent Claim
25 words
The method of claim 6 wherein the antihistamine is present in said antiperspirant composition in a small but perceptible amount to about 10% by weight.
Claim 18
Dependent Claim
28 words
The method of claim 6 wherein the antihistamine is present in said antiperspirant composition in an amount in the range of about 0.01% to about 5% by weight.
Claim 19
Dependent Claim
28 words
The method in claim 6 wherein the antihistamine is present in said antiperspirant composition in an amount in the range of about 0.01% to about 2% by weight.
Claim 20
Dependent Claim
13 words
The method of claim 6 wherein the controlling is the reduction of perspiration.
Claim 21
Dependent Claim
18 words
The method of claim 14 wherein the reduction of perspiration is carried out over a plurality of days.
Claim 22
Dependent Claim
16 words
The method of claim 15 wherein during that period the treated area is exposed to washing.
Claim 23
Dependent Claim
11 words
The method of claim 10 wherein the administration is by spray.
References Cited (Backward Citations)
US3624200A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |