US4233285A
Expired / Lapsed
US
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Mercaptocarboxylic acid radiopharmaceuticals
Assignee: Medi Physics Inc
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Filing: 1973-05-14
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Granted: 1980-11-11
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Expires: 1993-05-14
Abstract
Abstract Mercaptocarboxylic acid chelated heavy metal radioisotope pharmaceuticals and methods for making them.
Inventors
- 👤 Harry S. Winchell
- 👤 Tz-Hong Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:26
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K9/00; A61K9/0012; A61K9/0019; A61K2123/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
80 words
A radiopharmaceutical comprising a complex of a mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least one mercapto group with a radioactive heavy metal ion produced by reduction with stannous chloride in the presence of the chelating agent wherein said complex is formed at a pH of from about 2 to 4 and the mole ratio of said metal chelating agent to stannous chloride present to reduce such metal ion is about three to one.
Claim 2
Dependent Claim
80 words
A radiopharmaceutical comprising a complex of a mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least one mercapto group with a radioactive heavy metal ion produced by reduction with stannous chloride in the presence of the chelating agent wherein said complex is formed at a pH of from about 2 to 4 and the mole ratio of said metal chelating agent to stannous chloride present to reduce such metal ion is about three to one.
Claim 3
Dependent Claim
27 words
The radiopharmaceutical of claim 1 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid.
Claim 4
Dependent Claim
19 words
The radiopharmaceutical of claim 2 wherein said agent is 2,3-dimercaptosuccinic acid and said heavy metal ion is technetium 99m.
Claim 5
Dependent Claim
61 words
A reagent for producing a radiopharmaceutical comprising an aqueous solution containing mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least mercapto group, 99-m-technetium pertechnetate and stannous chloride, where the mole ratio of said chelating agent to stannous chloride is about 3 to 1 and the pH of said solution being from about 2 to about 4.
Claim 6
Dependent Claim
61 words
A reagent for producing a radiopharmaceutical comprising an aqueous solution containing mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least mercapto group, 99-m-technetium pertechnetate and stannous chloride, where the mole ratio of said chelating agent to stannous chloride is about 3 to 1 and the pH of said solution being from about 2 to about 4.
Claim 7
Dependent Claim
27 words
The composition of claim 4 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid.
Claim 8
Dependent Claim
11 words
The composition of claim 4 wherein said agent is 2,3-dimercaptosuccinic acid.
Claim 9
Independent Claim
87 words
A method of imaging the renal cortex, brain abnormalities, tumors and myocardial infarcts of a patient comprising intravenously injecting said patient with a radiopharmaceutical comprising a complex of a mercaptocarboxylic acid metal chelating agent with a radioactive heavy metal ion produced by reduction with stannous chloride, wherein said complex is formed at a pH of from 2 to 4 and the mol ratio of said metal chelating agent to stannous chloride present to produce metal ion is about three to one, and scanning with a suitable apparatus.
Claim 10
Independent Claim
87 words
A method of imaging the renal cortex, brain abnormalities, tumors and myocardial infarcts of a patient comprising intravenously injecting said patient with a radiopharmaceutical comprising a complex of a mercaptocarboxylic acid metal chelating agent with a radioactive heavy metal ion produced by reduction with stannous chloride, wherein said complex is formed at a pH of from 2 to 4 and the mol ratio of said metal chelating agent to stannous chloride present to produce metal ion is about three to one, and scanning with a suitable apparatus.
Claim 11
Dependent Claim
27 words
The method of claim 7 wherein said chelating agent is selected from the group consisting of mercaptoacetic acid, 2-mercaptopropionic acid, 3-mercaptopropionic acid, mercaptosuccinic acid and 2,3-dimercaptosuccinic acid.
Claim 12
Dependent Claim
18 words
The method of claim 8 wherein said metal ion is technetium-99m and said chelating agent is 2,3-dimercaptosuccinic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-11 | 1984-05-12 | 1984-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-11 | 1988-05-12 | 1988-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-11 | 1992-05-12 | 1992-11-11 | $7700.00 | Window Closed / Lapsed |