Pulsatile blood pumping apparatus and method

Claim 2

A pulsatile fluid pumping system for circulating blood or blood-like fluids within the vascular systems of living tissue under automatically controlled and predetermined plural physiologic parameters, said system comprising: a pulsatile pump adapted for connection to said living tissue and having plural pumping parameters which may be independently controlled during cyclic operation of the pump, and sensing and control means for simultaneously monitoring plural predetermined physiologic parameters of said living tissue and for simultaneously controlling the plural independent pumping parameters as a predetermined logical function of said plural physiologic parameters so as to substantially maintain all such physiologic parameters at respectively corresponding predetermined values.

Claim 3

A pulsatile fluid pumping system as in claim 1 wherein said sensing and control means includes means for monitoring physiologic parameters including the systolic pressure, diastolic pressure and repetition rate of a blood pressure waveform produced in the vascular system of said living tissue.

Claim 4

A pulsatile fluid pumping system as in claim 1 or 2 wherein said pulsatile pump includes means permitting control of independent pumping parameters including the driving speed, stroke length and repetition rate of a reciprocating piston.

Claim 5

A pulsatile fluid pumping system as in claim 1 wherein: said sensing and control means includes means for monitoring physiologic parameters including the systolic pressure (SP), the diastolic pressure (DP) and repetition rate (HR) of a blood pressure waveform produced in the vascular system of said living tissue; said pulsatile pump includes means permitting control of independent pumping parameters including the delivery time (PDT) required for the pump to eject a certain delivery volume (PDV) of fluid; said pump being controlled by said sensing and control means to begin a new cycle of operation each time a predetermined desired DP level is sensed and to alter PDT and PDV parameters as set forth in the following logical function table to maintain SP and HR parameters at predetermined desired values: ______________________________________ to to increase SP decrease SP satisfactory SP ______________________________________ to increase decrease decrease PDT decrease PDV HR PDT decrease PDV HR satis- decrease no change increase PDT factory PDT decrease PDV increase PDV to decrease increase increase PDT increase PDT HR PDV increase PDV ______________________________________

Claim 6

An extracorporeal pulsatile fluid pumping system for circulating blood or blood-like fluids within living tissue under automatically controlled and predetermined plural physiologic parameters, said system comprising: a cyclically operated pulsatile fluid pump which, when supplied with a fluid, operates at a controllable pump delivery speed (PDS) to deliver to said living tissue a controllable pump delivery volume (PDV) of fluid in a pump cycle time (PCT) period; at least one sensor and feedback circuit adapted to monitor a plurality of predetermined physiologic parameters within said living tissue and to provide a respectively corresponding plurality of first electrical signals representing the actual instantaneous values of such parameters in the living tissue; a plurality of manually adjustable input controls which provide a plurality of second electrical signals each representing the desired value for a respectively corresponding one of said predetermined physiologic parameters; and control circuits connected to receive said first and second electrical signals, to compare said actual instantaneous values with the respectively corresponding desired values and to control two or more of the pump parameters PDS, PDV and PCT as a predetermined function of said comparison so as to correct for detected deviations of the actual values from the desired values.

Claim 7

An extracorporeal pulsatile fluid pumping system for circulating blood or blood-like fluids within living tissue under automatically controlled and predetermined plural physiologic parameters, said system comprising: a cyclically operated pulsatile fluid pump which, when supplied with a fluid, operates at a controllable pump delivery speed (PDS) to deliver to said living tissue a controllable pump delivery volume (PDV) of fluid in a pump cycle time (PCT) period; at least one sensor and feedback circuit adapted to monitor a plurality of predetermined physiologic parameters within said living tissue and to provide a respectively corresponding plurality of first electrical signals representing the actual instantaneous values of such parameters in the living tissue; a plurality of manually adjustable input controls which provide a plurality of second electrical signals each representing the desired value for a respectively corresponding one of said predetermined physiologic parameters; and control circuits connected to receive said first and second electrical signals, to compare said actual instantaneous values with the respectively corresponding desired values and to control two or more of the pump parameters PDS, PDV and PCT as a predetermined function of said comparison so as to correct for detected deviations of the actual values from the desired values.

Claim 8

A pulsatile fluid pumping system as in claim 5 wherein the control circuits include means adapted to control two or more of the PDS, PDV and PCT pump parameters as a function of detected changes in one or more of the physiologic parameters of systolic fluid pressure (SP) diastolic fluid pressure (DP) and pressure wave repetition period or heart period (HP) in accordance with the following tabulation where "↑" represents "increase," "↓" represents "decrease," and "-" represents "no change": ______________________________________ Possible controlled change Detected deviation of in PDS, PDV and/or PCT to SP, DP and/or HP from correct for detected physio- desired normal values logical deviation SP DP HR(1/HP) PDS PDV PCT ______________________________________ ↑ = ↑ ↓ - = ↓ = ↓ ↑ - = ↑ = ↓ - ↓ = ↓ = ↑ - ↑ = ↑ = - ↓ ↓ = ↓ = - ↑ ↑ = - = ↑ ↓ ↑ = - = ↓ ↑ ↓ = ↑ ↓ = ↓ - = ↓ ↑ = ↑ - = ↑ ↑ = - ↓ = ↓ ↓ = - ↑ = ↑ - = ↓ ↓ = ↓ - = ↑ ↑ = - ↓ = ↓ ↑ = - ↑ = ↑ ↓ = ______________________________________

Claim 9

A pulsatile fluid pumping system as in claim 5 wherein said sensor and feedback circuit includes means for monitoring said plurality of physiologic parameters including at least two of the systolic blood pressure, diastolic blood pressure and heart period parameters.

Claim 10

A pulsatile fluid pumping system as in any of claims 1, 2, 4, 5, 6 or 7 including visual display means connected to monitor and display visual indications related to said plurality of predetermined physiologic parameters.

Claim 11

In a pulsatile fluid pumping system for circulating blood or blood-like fluids within the vascular system of living tissue, the improvement comprising: sensor means for sensing plural predetermined physiologic parameters within said living tissue; input means for presenting a predetermined desired value for each of said plural physiologic parameters; comparing means connected for comparing each of the sensed plural physiologic parameter values with its respectively corresponding predetermined desired value and providing corresponding plural output signals respectively representing detected deviations therefrom; and control means connected for controlling plural independent pumping parameters of said pumping system in response to a predetermined logical function of said detected deviations.

Claim 12

In a pulsatile fluid pumping system for circulating blood or blood-like fluids within the vascular system of living tissue, the improvement comprising: sensor means for sensing plural predetermined physiologic parameters within said living tissue; input means for presenting a predetermined desired value for each of said plural physiologic parameters; comparing means connected for comparing each of the sensed plural physiologic parameter values with its respectively corresponding predetermined desired value and providing corresponding plural output signals respectively representing detected deviations therefrom; and control means connected for controlling plural independent pumping parameters of said pumping system in response to a predetermined logical function of said detected deviations.

Claim 13

An improvement as in claim 9 wherein said sensor means includes means for monitoring physiologic parameters including the systolic pressure, diastolic pressure and repetition rate of a blood pressure waveform produced in the vascular system of said living tissue.

Claim 14

An improvement as in claims 9 or 10 wherein said pumping system includes means permitting control of independent pumping parameters including the driving speed, stroke length and repetition rates of a reciprocating piston.

Claim 15

An improvement as in claim 9 wherein: said sensor means includes means for monitoring physiologic parameters including the systolic pressure (SP), the diastolic pressure (DP) and repetition rate (HR) of a blood pressure waveform produced in the vascular system of said living tissue; said pumping system includes means permitting control of independent pumping parameters including the delivery time (PDT) required for the pumping system to eject a certain delivery volume (PDV) of fluid; said pumping system being controlled by said control means to begin a new cycle of operation each time a predetermined desired DP level is sensed and to alter PDT and PDV parameters as set forth in the following logical function table to maintain SP and HR parameters at predetermined desired values: ______________________________________ to to increase SP decrease SP satisfactory SP ______________________________________ to increase decrease decrease PDT decrease PDV HR PDT decrease PDV HR satis- decrease no change increase PDT factory PDT decrease PDV increase PDV to decrease increase increase PDT increase PDT HR PDV increase PDV ______________________________________

Claim 18

A method as in claim 13 wherein said physiologic parameters comprise the systolic pressure, diastolic pressure and repetition rate of a blood pressure waveform produced in the vascular system of said living tissue.

Claim 19

A method as in claim 13 or 14 wherein said independent pumping parameters comprise the driving speed, stroke length and repetition rate of a reciprocating piston.

Claim 20

A method as in claim 13 wherein: said physiologic parameters comprise the systolic pressure (SP), the diastolic pressure (DP) and repetition rate (HR) of a blood pressure waveform produced in the vascular system of said living tissue; said independent pumping parameters comprise the delivery time (PDT) required for the pump to eject a certain delivery volume (PDV) of fluid; said pump being controlled to begin a new cycle of operation each time a predetermined desired DP level is sensed and to alter PDT and PDV parameters as set forth in the following logical function table to maintain SP and HR parameters at predetermined desired values: ______________________________________ to to increase SP decrease SP satisfactory SP ______________________________________ to increase decrease decrease PDT decrease PDV HR PDT decrease PDV HR satis- decrease no change increase PDT factory PDT decrease PDV increase PDV to decrease increase increase PDT increase PDT HR PDV increase PDV ______________________________________

Claim 23

A method as in claim 17 wherein two or more of the PDS, PDV and PCT pump parameters are controlled as a function of detected changes in one or more of the physiologic parameters of systolic fluid pressure (SP) diastolic fluid pressure (DP) and pressure wave repetition period or heart period (HP) in accordance with the following tabulation where "↑" represents "increase," "↓" represents "decrease," and "-" represents "no change". ______________________________________ Possible controlled change Detected deviation of in PDS, PDV and/or PCT to SP, DP and/or HP from correct for detected physio- desired normal values logical deviation SP DP HR(1/HP) PDS PDV PCT ______________________________________ ↑ = ↑ ↓ - = ↓ = ↓ ↑ - = ↑ = ↓ - ↓ = ↓ = ↑ - ↑ = ↑ = - ↓ ↓ = ↓ = - ↑ ↑ = - = ↑ ↓ ↑ = - = ↓ ↑ ↓ = ↑ ↓ = ↓ - = ↓ ↑ = ↑ - = ↑ ↑ = - ↓ = ↓ ↓ = - ↑ = ↑ - = ↓ ↓ = ↓ - = ↑ ↑ = - ↓ = ↓ ↑ = - ↑ = ↑ ↓ = ______________________________________

Claim 24

A method as in claim 17 wherein said plurality of physiologic parameters include at least two of the systolic blood pressure, diastolic blood pressure and heart period parameters.

Claim 26

An improved method for pulsatile circulation of blood or blood-like fluids within the vascular system of living tissue, said improved method comprising: sensing plural predetermined physiologic parameters within said living tissue; manually providing a predetermined desired value for each of said plural physiologic parameters; comparing each of the sensed plural physiologic parameter values with its respectively corresponding predetermined desired value and providing corresponding plural output signals respectively representing detected deviations therefrom; and controlling plural independent pumping parameters of said pumping system in response to a predetermined logical function of said detected deviations.

Claim 27

An improved method for pulsatile circulation of blood or blood-like fluids within the vascular system of living tissue, said improved method comprising: sensing plural predetermined physiologic parameters within said living tissue; manually providing a predetermined desired value for each of said plural physiologic parameters; comparing each of the sensed plural physiologic parameter values with its respectively corresponding predetermined desired value and providing corresponding plural output signals respectively representing detected deviations therefrom; and controlling plural independent pumping parameters of said pumping system in response to a predetermined logical function of said detected deviations.

Claim 28

An improved method as in claim 21 wherein said physiologic parameters comprise the systolic pressure, diastolic pressure and repetition rate of a blood pressure waveform produced in the vascular system of said living tissue.

Claim 29

An improved method as in claims 21 or 22 wherein said independent pumping parameters comprise the driving speed, stroke length and repetition rates of a reciprocating piston.

Claim 30

An improved method as in claim 21 wherein: said physiologic parameters comprise the systolic pressure (SP), the diastolic pressure (DP) and repetition rate (HR) of a blood pressure waveform produced in the vascular system of said living tissue; said independent pumping parameters comprise the delivery time (PDT) required for the pumping system to eject a certain delivery volume (PDV) of fluid; said pumping system being controlled to begin a new cycle of operation each time a predetermined desired DP level is sensed and to alter PDT and PDV parameters as set forth in the following logical function table to maintain SP and HR parameters at predetermined desired values: ______________________________________ to to increase SP decrease SP satisfactory SP ______________________________________ to increase decrease decrease PDT decrease PDV HR PDT decrease PDV HR satis- decrease no change increase PDT factory PDT decrease PDV increase PDV to decrease increase increase PDT increase PDT HR PDV increase PDV ______________________________________