US4230700A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for inhibiting mobilization of calcium phosphate in animal tissue
Assignee: Procter and Gamble Co
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Filing: 1977-12-07
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Granted: 1980-10-28
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Expires: 1997-12-07
Abstract
Abstract Compositions for inhibiting the anomalous mobilization of calcium phosphates in animal tissue comprising an effective amount of certain phosphonate compounds as herein defined in combination with Vitamin D-like antirachitic compounds, and a method for treating or preventing conditions involving hard tissue demineralization in an animal comprising concurrently administering said phosphonates and Vitamine D-like antirachitic compounds to animals.
Inventors
- 👤 Marion D. Francis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 20:45
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/665
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
203 words
A method of treating Paget's disease comprising conjointly administering to an animal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of: ##STR9## wherein each p is hydrogen or CH 2 OH and n is an integer of from 3 to 10: ##STR10## wherein R 1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , CH(PO 3 H 2 )(OH), or --[CH 2 C(PO 3 H 2 ) 2 ] n H wherein n is 1 to 15, R 2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2; ##STR11## wherein n is an integer of from 3 to 9; ##STR12## wherein each R 3 is hydrogen or lower alkyl; ##STR13## wherein n is an integer of from 2 to 4; ##STR14## wherein X and Y are each hydrogen or hydroxy; ##STR15## and the pharmaceutically acceptable salts thereof; and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
Claim 2
Independent Claim
203 words
A method of treating Paget's disease comprising conjointly administering to an animal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of: ##STR9## wherein each p is hydrogen or CH 2 OH and n is an integer of from 3 to 10: ##STR10## wherein R 1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , CH(PO 3 H 2 )(OH), or --[CH 2 C(PO 3 H 2 ) 2 ] n H wherein n is 1 to 15, R 2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2; ##STR11## wherein n is an integer of from 3 to 9; ##STR12## wherein each R 3 is hydrogen or lower alkyl; ##STR13## wherein n is an integer of from 2 to 4; ##STR14## wherein X and Y are each hydrogen or hydroxy; ##STR15## and the pharmaceutically acceptable salts thereof; and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
Claim 3
Independent Claim
203 words
A method of treating osteoporosis comprising conjointly administering to an aminal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of: ##STR16## wherein each P is hydrogen or CH 2 CH and n is an integer of from 3 to 10: ##STR17## wherein R 1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , CH(PO 3 H 2 )(OH), or --[CH 2 C(PO 3 H 2 ) 2 ] n H wherein n is 1 to 15, R 2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; ##STR18## wherein n is an integer of from 3 to 9: ##STR19## wherein each P 3 is hydrogen or lower alkyl; ##STR20## wherein n is an integer of from 2 to 4; ##STR21## wherein X and Y are each hydrogen or hydroxy; ##STR22## and the pharmaceutically acceptable salts thereof, and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
Claim 4
Independent Claim
203 words
A method of treating osteoporosis comprising conjointly administering to an aminal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of: ##STR16## wherein each P is hydrogen or CH 2 CH and n is an integer of from 3 to 10: ##STR17## wherein R 1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH 2 COOH, --CH 2 PO 3 H 2 , CH(PO 3 H 2 )(OH), or --[CH 2 C(PO 3 H 2 ) 2 ] n H wherein n is 1 to 15, R 2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH 2 COOH, --CH 2 PO 3 H 2 , or --CH 2 CH 2 PO 3 H 2 ; ##STR18## wherein n is an integer of from 3 to 9: ##STR19## wherein each P 3 is hydrogen or lower alkyl; ##STR20## wherein n is an integer of from 2 to 4; ##STR21## wherein X and Y are each hydrogen or hydroxy; ##STR22## and the pharmaceutically acceptable salts thereof, and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
Claim 5
Dependent Claim
19 words
The method of claim 1 or 2 wherein the phosphonate is ethane-1-hydroxy-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
19 words
The method of claim 1 or 2 wherein the phosphonate is dichloromethanediphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
18 words
The method of claim 1 or 2 wherein the phosphonate is tris(phosphonomethyl)amine or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
19 words
The method of claim 1 or 2 wherein the phosphonate is methanecyclohexylhydroxydiphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
18 words
The method of claim 1 or 2 wherein the phosphonate is 3,3,4,4,5,5-hexafluoro-1,2-diphosphonocyclopent-1-ene or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
20 words
The method of claim 1 or 2 wherein the phosphonate is cyclic tetraphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
19 words
The method of claim 1 or 2 wherein the phosphonate is ethene-1,2-dicarboxy-1-phosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
19 words
The method of claim 1 or 2 wherein the phosphonate is ethane-1,2-dicarboxy-1,2-diphosphonic acid or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
51 words
The method of claim 1 or 2 wherein the Vitamin D-active antirachitic compound is selected from the group consisting of Vitamin D 2 ; Vitamin D 3 ; dihyrdoxytachysterol 2 ; dihydrotachysterol 3 ; 25-hydroxydihydrotachysterol 3 ; 25-hydroxyergocalciferol; 25-hydroxycholecalciferol; 1α,25-dihydroxycholecalciferol; 5,6-trans-cholecalciferol; 5,6-trans-25-hydroxycholecalciferol; 24-nor-25-hydroxycholecalciferol; 24-nor-5,6-trans-25-hydroxycholecalciferol; 21,25-dihydroxycholecalciferol; 25,26-dihydroxycholecalciferol; 24,25-dihydroxycholecalciferol; 1α-hydroxycholecalciferol; and mixtures thereof.
Claim 14
Dependent Claim
16 words
The method of claim 1 or 2 wherein the antirachitic compound is Vitamin D 3 .
Claim 15
Dependent Claim
14 words
The method of claim 3 wherein the antirachitic compound is Vitamin D 3 .
Claim 16
Dependent Claim
14 words
The method of claim 4 wherein the antirachitic compound is Vitamin D 3 .
Claim 17
Dependent Claim
13 words
The method of claim 1 or 2 wherein the antirachitic compound is 1α-hydroxycholecalciferol.
Claim 18
Dependent Claim
11 words
The method of claim 3 wherein the antirachitic compound is 1α-hydroxycholecalciferol.
Claim 19
Dependent Claim
11 words
The method of claim 4 wherein the antirachitic compound is 1α-hydroxycholecalciferol.
Claim 20
Dependent Claim
11 words
The method of claim 5 wherein the antirachitic compound is 1α-hydroxycholecalciferol.
Claim 21
Dependent Claim
18 words
The method of claim 1 or 2 wherein the Vitamin-D active antirachitic compound is Vitamin D 2 .
Claim 22
Dependent Claim
16 words
The method of claim 3 wherein the Vitamin-D active antirachitic compound is Vitamin D 2 .
Claim 23
Dependent Claim
16 words
The method of claim 4 wherein the Vitamin-D active antirachitic compound is Vitamin D 2 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |