US4230635A
Expired / Lapsed
US
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Substituted 4'-polyhaloisopropylsulfonanilides
Assignee: Merck Sharp & Dohme LLC
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Filing: 1978-08-15
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Granted: 1980-10-28
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Expires: 1998-08-15
Abstract
Abstract Disclosed are novel substituted 4'-polyhaloisopropylsulfonanilides which are anti-hypertensive agents useful in the treatment of mammalian hypertension. Additionally, the compounds exhibit herbicidal and fungicidal activity. The compounds are prepared by contacting a 4-polyhaloisopropylaniline with the appropriate substituted-sulfonyl chloride.
Inventors
- 👤 Bernard R. Neustadt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:01
CPC Classifications
A; A01; A01N; A01N41/00; A01N41/02; A01N41/04; A01N41/08; A01N41/06; A01N47/00; A01N47/08; A01N47/10; A01N47/24; A01N47/28; A01N47/34
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
86 words
A compound of the formula: ##STR5## wherein R is hydrogen, lower alkyl, or a lower alkylsulfonyl group; R 1 is hydrogen, lower alkyl, lower alkoxy, or halogen; R 2 is hydrogen, lower alkyl, lower alkoxy, or halogen; R 3 is hydrogen or lower alkyl, or R 1 and R 3 together complete an aromatic fused hydrocarbon ring; R 4 is lower alkyl; Y, Y 1 , Y 2 , and Y 3 are independently hydrogen, chlorine or fluorine; and Z is hydrogen, chlorine, fluorine, or hydroxy.
Claim 2
Dependent Claim
86 words
A compound of the formula: ##STR5## wherein R is hydrogen, lower alkyl, or a lower alkylsulfonyl group; R 1 is hydrogen, lower alkyl, lower alkoxy, or halogen; R 2 is hydrogen, lower alkyl, lower alkoxy, or halogen; R 3 is hydrogen or lower alkyl, or R 1 and R 3 together complete an aromatic fused hydrocarbon ring; R 4 is lower alkyl; Y, Y 1 , Y 2 , and Y 3 are independently hydrogen, chlorine or fluorine; and Z is hydrogen, chlorine, fluorine, or hydroxy.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 wherein Z is a hydroxy group.
Claim 4
Dependent Claim
22 words
A compound according to claim 2 wherein Y, Y 1 , Y 2 and Y 3 are each independently fluorine or chlorine.
Claim 5
Dependent Claim
19 words
A compound according to claim 2 wherein Y, Y 1 , Y 2 and Y 3 are each fluorine.
Claim 6
Dependent Claim
11 words
A compound according to claim 3 wherein R 3 is hydrogen.
Claim 7
Dependent Claim
15 words
A compound according to claim 3 wherein R is hydrogen and R 4 is methyl.
Claim 8
Dependent Claim
9 words
A compound according to claim 3 which is 2',6'-dimethyl-4'-(hexafluoro-2-hydroxy-2-propyl)methanesulfonanilide.
Claim 9
Dependent Claim
9 words
A compound according to claim 3 which is 2',6'-diethyl-4'-(hexafluoro-2-hydroxy-2-propyl)methanesulfonanilide.
Claim 10
Dependent Claim
9 words
A compound according to claim 3 which is 2'-bromo-4'-(hexafluoro-2-hydroxy-2-propyl)-6'-methylmethanesulfonanilide.
Claim 11
Dependent Claim
9 words
A compound according to claim 3 which is 4'-(hexafluoro-2-hydroxy-2-propyl)-2',6'-diisopropylmethanesulfonanilide.
Claim 12
Dependent Claim
9 words
A compound according to claim 3 which is 2'-bromo-4'-(hexafluoro-2-hydroxy-2-propyl)methanesulfonanilide.
Claim 13
Dependent Claim
9 words
A compound according to claim 3 which is 4'-(hexafluoro-2-hydroxy-2-propyl)-2'-methoxy-6'-methylmethanesulfonanilide.
Claim 14
Dependent Claim
9 words
A compound according to claim 3 which is 4'-(hexafluoro-2-hydroxy-2-propyl)-2'-methoxy-N-methylmethanesulfonanilide
Claim 15
Dependent Claim
9 words
A compound according to claim 3 which is 2',6'-dibromo-4'-(hexafluoro-2-hydroxy-2-propyl)methanesulfonanilide.
Claim 16
Dependent Claim
9 words
A compound according to claim 3 which is 4'-(hexafluoro-2-hydroxy-2-propyl)-2',6'-dimethoxymethanesulfonanilide.
Claim 17
Dependent Claim
9 words
A compound according to claim 3 which is 4'-(hexafluoro-2-hydroxy-2-propyl)-2'-methoxymethanesulfonanilide.
Claim 18
Dependent Claim
9 words
A compound according to claim 3 which is N-methanesulfonyl-2'-bromo-4'-(hexafluoro-2-hydroxy-2-propyl)-6'-methoxymethanesulfonanilide.
Claim 19
Dependent Claim
9 words
A compound according to claim 3 which is 2'-bromo-4'-(hexafluoro-2-hydroxy-2-propyl)-6'-methoxymethanesulfonanilide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |