US4228099A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders
Assignee: Johns Hopkins University
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Filing: 1978-03-17
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Granted: 1980-10-14
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Expires: 1998-03-17
Abstract
Abstract Novel compounds are prepared by reacting ornithine or arginine with alpha keto analogs of branched chain essential amino acids, namely valine, leucine and isoleucine. The compounds are useful either individually or as a mixture in the treatment of hepatic disorders which are characterized by hyperammonemia and portal systemic encephalopathy. Use of these compounds in treatment of renal failure also appears promising.
Inventors
- 👤 Mackenzie Walser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:01
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/185; A; A61; A61P; A61P1/00; A61P1/16; A61P13/00; A61P13/02; A61P15/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
39 words
Compounds of the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
Claim 2
Dependent Claim
39 words
Compounds of the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
Claim 3
Dependent Claim
13 words
Compounds according to claim 1 wherein A is ornithine and x is zero.
Claim 4
Dependent Claim
2 words
Arginine α-ketoisocaproate.
Claim 5
Dependent Claim
2 words
Arginine α-ketoisocaproate.
Claim 6
Dependent Claim
2 words
Arginine α-ketoisovalerate.
Claim 7
Dependent Claim
2 words
Arginine α-ketoisovalerate.
Claim 8
Dependent Claim
2 words
Arginine α-keto-β-methylvalerate.
Claim 9
Dependent Claim
2 words
Arginine α-keto-β-methylvalerate.
Claim 10
Dependent Claim
2 words
Ornithine α-ketoisocaproate.
Claim 11
Dependent Claim
2 words
Ornithine α-ketoisocaproate.
Claim 12
Dependent Claim
2 words
Ornithine α-ketoisovalerate.
Claim 13
Dependent Claim
2 words
Ornithine α-ketoisovalerate.
Claim 14
Dependent Claim
2 words
Ornithine α-keto-β-methylvalerate.
Claim 15
Dependent Claim
2 words
Ornithine α-keto-β-methylvalerate.
References Cited (Backward Citations)
CA814483A
Cited
GB1034358A
Cited
FR1432756A
Cited
US3441650A
Cited
FR2226993B1
Cited
US4100293A
Cited
US3950529A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-14 | 1984-04-14 | 1984-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-14 | 1988-04-14 | 1988-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-14 | 1992-04-14 | 1992-10-14 | $7700.00 | Window Closed / Lapsed |