US4228015A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Plasma treatment apparatus
Assignee: Baxter International Inc
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Filing: 1979-01-29
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Granted: 1980-10-14
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Expires: 1999-01-29
Abstract
Abstract A plasmapheresis system in which whole blood is filtered through a microporous membrane to provide a plasma filtrate. The system includes a filter cell assembly having a membrane support member, a treatment membrane spaced from the membrane support member with a plasma treatment agent sandwiched between the treatment membrane and the membrane support member, and a microporous membrane spaced from the treatment membrane to form a plasma chamber between the treatment membrane and the microporous membrane. Whole blood is introduced to the side of the microporous membrane opposite to the plasma chamber, plasma is filtered through the microporous membrane to the plasma chamber and the plasma filtrate contacts the treatment membrane which operates to provide a mass transfer between the treatment agent and the plasma filtrate. The treated plasma is withdrawn from the plasma chamber, is mixed with the plasma-poor whole blood and is returned to the patient.
Inventors
- 👤 James H. De Vries
- 👤 Gaylord L. Berry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 07:31
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3479; B; B01; B01D; B01D61/00; B01D61/14; B01D61/18; B01D63/00; B01D63/08; B01D63/082; B01D63/084
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
130 words
Plasma treatment apparatus in which whole blood is filtered through a microporous membrane having a pore size between 0.1 micron and 2 microns thereby providing a plasma filtrate, the improvement comprising, in combination: a filter cell assembly including said microporous membrane; said filter cell assembly having a membrane support member and a treatment membrane supported by said membrane support member; a plasma treatment agent sandwiched between said membrane support member and said treatment membrane; said treatment membrane being spaced from said microporous membrane to form a plasma chamber therebetween; said treatment membrane being operable to permit transfer between said treatment agent and the plasma in said plasma chamber; means for introducing whole blood to one side of said microporous membrane; and means for withdrawing treated plasma from said plasma chamber.
Claim 2
Dependent Claim
130 words
Plasma treatment apparatus in which whole blood is filtered through a microporous membrane having a pore size between 0.1 micron and 2 microns thereby providing a plasma filtrate, the improvement comprising, in combination: a filter cell assembly including said microporous membrane; said filter cell assembly having a membrane support member and a treatment membrane supported by said membrane support member; a plasma treatment agent sandwiched between said membrane support member and said treatment membrane; said treatment membrane being spaced from said microporous membrane to form a plasma chamber therebetween; said treatment membrane being operable to permit transfer between said treatment agent and the plasma in said plasma chamber; means for introducing whole blood to one side of said microporous membrane; and means for withdrawing treated plasma from said plasma chamber.
Claim 3
Dependent Claim
25 words
Plasma treatment apparatus as described in claim 1, including means for circulating said plasma treatment agent between said membrane support member and said treatment membrane.
Claim 4
Dependent Claim
20 words
Plasma treatment apparatus as described in claim 1, including spacer means positioned between said treatment membrane and said microporous membrane.
Claim 5
Dependent Claim
15 words
Plasma treatment apparatus as described in claim 3, said spacer means comprising a mesh screen.
Claim 6
Dependent Claim
33 words
Plasma treatment apparatus as described in claim 1, said means for introducing whole blood including a blood inlet port and a blood outlet port communicating with said one side of said microporous membrane.
Claim 7
Dependent Claim
40 words
Plasma treatment apparatus as described in claim 2, said plasma treatment agent circulation means including a treatment agent inlet port and a treatment agent outlet port communicating with the volume defined by the treatment membrane and the membrane support member.
Claim 8
Dependent Claim
196 words
Plasma treatment apparatus in which whole blood is filtered through a microporous membrane having a pore size between 0.1 micron and 2 microns thereby providing a plasma filtrate, the improvement comprising, in combination: a filter cell assembly including said microporous membrane; said filter cell assembly having a membrane support membrane and a treatment membrane supported by said membrane support member; a plasma treatment agent sandwiched between said membrane support member and said treatment membrane; a treatment agent inlet port and a treatment agent outlet port communicating with the volume defined by the treatment membrane and the membrane support member for circulating said plasma treatment agent between said membrane support member and said treatment membrane; means positioned between said treatment membrane and said microporous membrane for spacing said microporous membrane from said treatment membrane to form a plasma chamber therebetween; said treatment membrane being operable to permit transfer between said treatment agent and the plasma in said plasma chamber; a blood inlet port and a blood outlet port communicating with one side of said microporous membrane for circulating blood to said one side of said microporous membrane; and means for withdrawing treated plasma from said plasma chamber.
Claim 9
Dependent Claim
196 words
Plasma treatment apparatus in which whole blood is filtered through a microporous membrane having a pore size between 0.1 micron and 2 microns thereby providing a plasma filtrate, the improvement comprising, in combination: a filter cell assembly including said microporous membrane; said filter cell assembly having a membrane support membrane and a treatment membrane supported by said membrane support member; a plasma treatment agent sandwiched between said membrane support member and said treatment membrane; a treatment agent inlet port and a treatment agent outlet port communicating with the volume defined by the treatment membrane and the membrane support member for circulating said plasma treatment agent between said membrane support member and said treatment membrane; means positioned between said treatment membrane and said microporous membrane for spacing said microporous membrane from said treatment membrane to form a plasma chamber therebetween; said treatment membrane being operable to permit transfer between said treatment agent and the plasma in said plasma chamber; a blood inlet port and a blood outlet port communicating with one side of said microporous membrane for circulating blood to said one side of said microporous membrane; and means for withdrawing treated plasma from said plasma chamber.
Claim 10
Dependent Claim
22 words
Plasma treatment apparatus as described in claim 7, wherein said treatment membrane is spaced from said microporous membrane by a mesh screen.
Claim 11
Dependent Claim
159 words
Plasma treatment apparatus comprising: a filter cell assembly having a blood inlet, a blood outlet and a plasma outlet; a pair of microporous membranes forming a blood flow path therebetween; said microporous membranes having a pore size between 0.1 micron and 2 microns; a first membrane support member positioned on one side of said pair of microporous membranes and a second membrane support member positioned on the opposite side of said microporous membranes; a treatment membrane positioned intermediate each of said membrane support members and one of the microporous membranes; means for spacing each of said treatment membranes from the respective microporous membrane to form a plasma chamber between each of said treatment membranes and the respective microporous membrane; a plasma treatment agent sandwiched between each membrane support member and treatment membrane; means coupling said blood inlet and blood outlet to said blood flow path between said microporous membranes; and means coupling said plasma outlet to said plasma chambers.
Claim 12
Dependent Claim
159 words
Plasma treatment apparatus comprising: a filter cell assembly having a blood inlet, a blood outlet and a plasma outlet; a pair of microporous membranes forming a blood flow path therebetween; said microporous membranes having a pore size between 0.1 micron and 2 microns; a first membrane support member positioned on one side of said pair of microporous membranes and a second membrane support member positioned on the opposite side of said microporous membranes; a treatment membrane positioned intermediate each of said membrane support members and one of the microporous membranes; means for spacing each of said treatment membranes from the respective microporous membrane to form a plasma chamber between each of said treatment membranes and the respective microporous membrane; a plasma treatment agent sandwiched between each membrane support member and treatment membrane; means coupling said blood inlet and blood outlet to said blood flow path between said microporous membranes; and means coupling said plasma outlet to said plasma chambers.
Claim 13
Dependent Claim
49 words
Plasma treatment apparatus as described in claim 9, including a plasma treatment agent inlet and a plasma treatment agent outlet; means coupling said plasma treatment agent inlet and outlet to locations between each membrane support member and treatment membrane to form a circulation path for said plasma treatment agent.
Claim 14
Dependent Claim
15 words
Plasma treatment apparatus as described in claim 9, said spacing means comprising a mesh screen.
Claim 15
Dependent Claim
21 words
Plasma treatment apparatus as described in claim 9, said treatment membrane having a pore size that is less than 0.1 micron.
Claim 16
Dependent Claim
219 words
Plasma treatment apparatus comprising: a filter cell assembly having a blood inlet, a blood outlet and a plasma outlet; a pair of microporous membranes forming a blood flow path therebetween; said microporous membranes having a pore size between 0.1 micron and 2 microns; a first membrane support member positioned on one side of said pair of microporous membranes and a second membrane support member positioned on the opposite side of said microporous membranes; a treatment membrane positioned intermediate each of said membrane support members and one of the microporous membranes; means for spacing each of said treatment membranes from the respective microporous membrane to form a plasma chamber between each of said treatment membranes and the respective microporous membrane, said spacing means comprising a mesh screen; a plasma treatment agent sandwiched between each membrane support member and treatment membrane; a plasma treatment agent inlet and a plasma treatment agent outlet; means coupling said plasma treatment agent inlet and outlet to locations between each membrane support member and treatment membrane to form a circulation path for said plasma treatment agent; said treatment membrane having a pore size that is less than 0.1 micron; means coupling said blood inlet and blood outlet to said blood flow path between said microporous membranes; and means coupling said plasma outlet to said plasma chambers.
Claim 17
Dependent Claim
219 words
Plasma treatment apparatus comprising: a filter cell assembly having a blood inlet, a blood outlet and a plasma outlet; a pair of microporous membranes forming a blood flow path therebetween; said microporous membranes having a pore size between 0.1 micron and 2 microns; a first membrane support member positioned on one side of said pair of microporous membranes and a second membrane support member positioned on the opposite side of said microporous membranes; a treatment membrane positioned intermediate each of said membrane support members and one of the microporous membranes; means for spacing each of said treatment membranes from the respective microporous membrane to form a plasma chamber between each of said treatment membranes and the respective microporous membrane, said spacing means comprising a mesh screen; a plasma treatment agent sandwiched between each membrane support member and treatment membrane; a plasma treatment agent inlet and a plasma treatment agent outlet; means coupling said plasma treatment agent inlet and outlet to locations between each membrane support member and treatment membrane to form a circulation path for said plasma treatment agent; said treatment membrane having a pore size that is less than 0.1 micron; means coupling said blood inlet and blood outlet to said blood flow path between said microporous membranes; and means coupling said plasma outlet to said plasma chambers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-14 | 1984-04-14 | 1984-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-14 | 1988-04-14 | 1988-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-14 | 1992-04-14 | 1992-10-14 | $7700.00 | Window Closed / Lapsed |