US4226978A
Expired / Lapsed
US
⏱️ 0.0 years remaining
β-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their preparation
Assignee: Bayer Corp
•
Filing: 1978-03-13
•
Granted: 1980-10-07
•
Expires: 1998-03-13
Abstract
Abstract β-Galactosyl-umbelliferone labeled aminoglycoside antibiotics, e.g., gentamicin, useful in homogeneous and heterogeneous specific binding assays for such antibiotics in liquid media such as serum. Also provided are a β-galactosyl-umbelliferone-carboxylic acid and salts thereof which are intermediates in a method of preparing the labeled antibiotics.
Inventors
- 👤 Robert C. Boguslaski
- 👤 Robert J. Carrico
- 👤 John F. Burd
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:24
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D233/00; C07D233/54; C07D233/66; C07D233/72; C07D233/76; C07D233/78; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/075; C07H21/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/533; G01N33/535
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
51 words
A β-galactosyl-umbelliferone-labeled aminoglycoside antibiotic conjugate of the formula: ##STR25## wherein --NH)L is an aminoglycoside antibiotic selected from gentamicin, tobramycin, amikacin, kanamycin, sisomicin, or netilmicin bound through an amino group thereof by an amide bond and n equals 1 to the total number of primary amino groups in the selected antibiotic, inclusive.
Claim 2
Dependent Claim
51 words
A β-galactosyl-umbelliferone-labeled aminoglycoside antibiotic conjugate of the formula: ##STR25## wherein --NH)L is an aminoglycoside antibiotic selected from gentamicin, tobramycin, amikacin, kanamycin, sisomicin, or netilmicin bound through an amino group thereof by an amide bond and n equals 1 to the total number of primary amino groups in the selected antibiotic, inclusive.
Claim 3
Dependent Claim
9 words
The conjugate of claim 1 wherein L is gentamicin.
Claim 4
Dependent Claim
9 words
The conjugate of claim 1 wherein L is tobramycin.
Claim 5
Dependent Claim
9 words
The conjugate of claim 1 wherein L is amikacin.
Claim 6
Dependent Claim
9 words
The conjugate of claim 1 wherein L is kanamycin.
Claim 7
Dependent Claim
9 words
The conjugate of claim 1 wherein L is sisomicin.
Claim 8
Dependent Claim
9 words
The conjugate of claim 1 wherein L is netilmicin.
Claim 9
Dependent Claim
13 words
A compound of the formula: ##STR26## wherein Z is hydrogen, potassium or sodium.
Claim 10
Dependent Claim
13 words
A compound of the formula: ##STR26## wherein Z is hydrogen, potassium or sodium.
Claim 11
Dependent Claim
9 words
The compound of claim 8 wherein Z is potassium.
Claim 12
Dependent Claim
9 words
The compound of claim 8 wherein Z is sodium.
Claim 13
Dependent Claim
9 words
The compound of claim 8 wherein Z is hydrogen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-07 | 1984-04-07 | 1984-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-07 | 1988-04-07 | 1988-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-07 | 1992-04-07 | 1992-10-07 | $7700.00 | Window Closed / Lapsed |