US4226878A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Imidazole derivative
Assignee: Kissei Pharmaceutical Co Ltd
•
Filing: 1979-06-13
•
Granted: 1980-10-07
•
Expires: 1999-06-13
Abstract
Abstract Novel imidazole derivatives of the general formula (I): ##STR1## wherein Y is a carboxyl group, an alkoxycarbonyl group, a cyano group, a hydroxymethyl group, an aminomethyl group, a formyl group or a carbamoyl group, and A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group, and n and m, which may be the same or different, each is zero or 1, with the proviso that when A is methylene group or n is zero, m is 1; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for the treatment of inflammation, hypertension, thrombus, cerebral apoplexy and asthma.
Inventors
- 👤 Kinji Iizuka
- 👤 Kenji Akahane
- 👤 Denichi Momose
- 👤 Yukio Kamijo
- 👤 Yukiyoshi Ajisawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:22
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P29/00; A61P43/00; A61P7/00; A61P9/00; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
82 words
A compound of the formula: ##STR31## wherein Y is a carboxyl group or an alkoxycarbonyl group having 2 to 7 carbon atoms, A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, n and m are zero or 1, with the proviso that the aggregate number of the linear carbon atoms in A and B is 2, 3 or 4; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
82 words
A compound of the formula: ##STR31## wherein Y is a carboxyl group or an alkoxycarbonyl group having 2 to 7 carbon atoms, A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, n and m are zero or 1, with the proviso that the aggregate number of the linear carbon atoms in A and B is 2, 3 or 4; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
25 words
A compound as claimed in claim 1 of the formula: ##STR32## wherein A, n, B and m have the same meanings as in claim 1.
Claim 4
Dependent Claim
39 words
A compound as claimed in claim 1 of the formula: ##STR33## wherein R is a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, A, n, B and m have the same meanings as in claim 1.
Claim 5
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR34##
Claim 6
Dependent Claim
11 words
The compound as caimed in claim 2 of the formula: ##STR35##
Claim 7
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR36##
Claim 8
Dependent Claim
11 words
The compound as caimed in claim 2 of the formula: ##STR37##
Claim 9
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR38##
Claim 10
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR39##
Claim 11
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR40##
Claim 12
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR41##
Claim 13
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR42##
Claim 14
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR43##
Claim 15
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR44##
Claim 16
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR45##
Claim 17
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR46##
Claim 18
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR47##
Claim 19
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR48##
Claim 20
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR49##
Claim 21
Dependent Claim
52 words
A pharmaceutical composition for alleviating diseases caused by thromboxane A 2 in mammals for oral administration containing, as an active ingredient, a compound of claim 1 in an amount in the range of about 1 to about 1000 mg per day per body in combination with a pharmaceutically acceptable carrier or diluent.
Claim 22
Dependent Claim
52 words
A pharmaceutical composition for alleviating diseases caused by thromboxane A 2 in mammals for parenteral administration containing, as an active ingredient, a compound of claim 1 in an amount in the range of about 0.1 to about 100 mg per day per body in combination with a pharmaceutically acceptable carrier or diluent.
Claim 23
Dependent Claim
26 words
A method of alleviating the diseases caused by thromboxane A 2 in mammals which comprises administering a therapeutically effective amount of a compound of claim 1.
References Cited (Backward Citations)
GB1119334A
Cited
US3531494A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-07 | 1984-04-07 | 1984-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-07 | 1988-04-07 | 1988-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-07 | 1992-04-07 | 1992-10-07 | $7700.00 | Window Closed / Lapsed |