US4226875A
Expired / Lapsed
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Novel spiro-oxazolidinediones
Assignee: Pfizer Inc
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Filing: 1979-04-02
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Granted: 1980-10-07
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Expires: 1999-04-02
Abstract
Abstract Novel spiro-oxazolidinediones useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Pharmaceutical compositions containing the novel compounds and a method of treating chronic diabetic complications are also disclosed.
Inventors
- 👤 Rodney C. Schnur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:32
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/52; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
51 words
A compound of the formula ##STR8## and the pharmaceutically acceptable salts thereof, wherein n is zero or one; R and R 2 are each hydrogen; and R 1 and R 3 are each selected from the group consisting of hydrogen, chloro, bromo, fluoro and alkyl of 1 to 3 carbon atoms.
Claim 2
Dependent Claim
51 words
A compound of the formula ##STR8## and the pharmaceutically acceptable salts thereof, wherein n is zero or one; R and R 2 are each hydrogen; and R 1 and R 3 are each selected from the group consisting of hydrogen, chloro, bromo, fluoro and alkyl of 1 to 3 carbon atoms.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein n is one.
Claim 4
Dependent Claim
26 words
A compound according to claim 2 wherein R 1 and R 3 are each selected from the group consisting of hydrogen, chloro, bromo, fluoro and methyl.
Claim 5
Dependent Claim
15 words
A compound according to claim 3 wherein R 1 and R 3 are each hydrogen.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein n is zero.
Claim 7
Dependent Claim
26 words
A compound according to claim 5 wherein R 1 and R 3 are each selected from the group consisting of hydrogen, chloro, bromo, fluoro and methyl.
Claim 8
Dependent Claim
15 words
A compound according to claim 6 wherein R 1 and R 3 are each hydrogen.
Claim 9
Dependent Claim
24 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1 in an amount effective for the treatment of diabetes-associated complications.
Claim 10
Dependent Claim
25 words
A method for treating a diabetic host for diabetes-associated complications, which comprises administering to said host an effective amount of a compound of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-07 | 1984-04-07 | 1984-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-07 | 1988-04-07 | 1988-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-07 | 1992-04-07 | 1992-10-07 | $7700.00 | Window Closed / Lapsed |