US4221813A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of hypertension
Assignee: Merck and Co Inc
•
Filing: 1978-09-25
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Granted: 1980-09-09
•
Expires: 1998-09-25
Abstract
Abstract A method of treating hypertension by oral administration of the ethyl ester of L- alpha -methyl-3,4-dihydroxyphenylalanine or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions are disclosed.
Inventors
- 👤 George O. Breault
- 👤 King C. Kwan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/235; A61K31/24
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
38 words
A method of treating hypertension which comprises oral administration in non-liquid form once daily to a hypertensive human of about 750 mg. to about 2500 mg. of the ethyl ester of L-α-methyl-3,4-dihydroxyphenylalanine, or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
38 words
A method of treating hypertension which comprises oral administration in non-liquid form once daily to a hypertensive human of about 750 mg. to about 2500 mg. of the ethyl ester of L-α-methyl-3,4-dihydroxyphenylalanine, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said dose is about 750 mg.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said dose is about 1000 mg.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said dose is about 1500 mg.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said dose is about 2000 mg.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein said dose is administered in a single dosage unit.
Claim 8
Dependent Claim
42 words
A pharmaceutical composition in a unit dosage non-liquid form of a capsule or tablet for oral administration to a hypertensive human comprising about 750 mg. to about 2500 mg. of L-α-methyl-3,4-dihydroxyphenylalanine or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable compounding ingredient.
Claim 9
Dependent Claim
42 words
A pharmaceutical composition in a unit dosage non-liquid form of a capsule or tablet for oral administration to a hypertensive human comprising about 750 mg. to about 2500 mg. of L-α-methyl-3,4-dihydroxyphenylalanine or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable compounding ingredient.
Claim 10
Dependent Claim
19 words
The composition of claim 7 wherein said dosage form contains about 2000 mg. of said ester or salt thereof.
Claim 11
Dependent Claim
19 words
The composition of claim 7 wherein said dosage form contains about 750 mg. of said ester or salt thereof.
Claim 12
Dependent Claim
19 words
The composition of claim 7 wherein said dosage form contains about 1000 mg. of said ester or salt thereof.
Claim 13
Dependent Claim
19 words
The composition of claim 7 wherein said dosage form contains about 1500 mg. of said ester or salt thereof.
Claim 14
Dependent Claim
19 words
The composition of claim 6 wherein said dosage form contains about 2000 mg. of said ester or salt thereof.
Claim 15
Dependent Claim
19 words
The composition of claim 6 wherein said dosage form contains about 2500 mg. of said ester or salt thereof.
References Cited (Backward Citations)
US3230143A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-09 | 1984-03-10 | 1984-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-09 | 1988-03-10 | 1988-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-09 | 1992-03-10 | 1992-09-09 | $7700.00 | Window Closed / Lapsed |