US4221780A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for producing high potency factor VIII
Assignee: Ferring Pharmaceuticals Inc
•
Filing: 1978-12-04
•
Granted: 1980-09-09
•
Expires: 1998-12-04
Abstract
Abstract Factor VIII preparations of enhanced potency are obtained from human blood donors by recovering blood from donors who have been treated with 1-deamino-8-D-arginine vasopressin, in an amount sufficient to increase the circulating blood level of Factor VIII in the donor.
Inventors
- 👤 Joseph H. Cort
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:53
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00; A61K38/04; A61K38/08; A61K38/095; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
66 words
In a method for producing a Factor VIII preparation comprising collecting blood from a donor, separating the plasma therefrom, and recovering a Factor VIII-rich fraction from said plasma, the improvement of administering to said donor 1-deamino-8-D-arginine vasopressin in an amount effective to increase the circulating level of Factor VIII in the blood of said donor and thereafter recovering blood containing said increased levels of Factor VIII.
Claim 2
Dependent Claim
66 words
In a method for producing a Factor VIII preparation comprising collecting blood from a donor, separating the plasma therefrom, and recovering a Factor VIII-rich fraction from said plasma, the improvement of administering to said donor 1-deamino-8-D-arginine vasopressin in an amount effective to increase the circulating level of Factor VIII in the blood of said donor and thereafter recovering blood containing said increased levels of Factor VIII.
Claim 3
Dependent Claim
20 words
A method according to claim 1 wherein said amount is a circulating drug dosage of at least about 10 micrograms.
Claim 4
Dependent Claim
22 words
A method according to claim 1 wherein said amount is a circulating drug dosage of from about 10 to about 20 micrograms.
Claim 5
Dependent Claim
11 words
A method according to claim 1 wherein said administration is intravenously.
Claim 6
Dependent Claim
11 words
A method according to claim 1 wherein said administration is intranasally.
References Cited (Backward Citations)
US3497491A
Cited
US4104266A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-09 | 1984-03-10 | 1984-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-09 | 1988-03-10 | 1988-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-09 | 1992-03-10 | 1992-09-09 | $7700.00 | Window Closed / Lapsed |