US4218462A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids
Assignee: Merck and Co Inc
•
Filing: 1978-10-24
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Granted: 1980-08-19
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Expires: 1998-10-24
Abstract
Abstract Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen -2-em-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. <IMAGE> wherein R1 is, inter alia, substituted and unsubstituted alkyl, aryl and aralkyl.
Inventors
- 👤 Burton G. Christensen
- 👤 David H. Shih
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:43
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07C; C07C205/00; C07C205/39; C07C205/42; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20; C07D477/26; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07F9/00; C07F9/02; C07F9/547; C07F9/553; C07F9/568
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
83 words
A compound having the formula: ##STR83## and its pharmaceutically acceptable salts wherein R 1 is selected from the group consisting of substituted and unsubstituted loweralkyl having from 1-6 carbon atoms, phenyl, phenylloweralkyl, cycloalkyl having from 3 to 6 carbon atoms, and cycloalkylalkyl having 4 to 7 carbon atoms in the chain and 3-6 carbon atoms in the ring; wherein said substituents on R 1 are selected from the group consisting of halogen, hydroxyl, amino, alkyl having 1-6 carbon atoms, azido, cyano, and carboxyl.
Claim 2
Dependent Claim
83 words
A compound having the formula: ##STR83## and its pharmaceutically acceptable salts wherein R 1 is selected from the group consisting of substituted and unsubstituted loweralkyl having from 1-6 carbon atoms, phenyl, phenylloweralkyl, cycloalkyl having from 3 to 6 carbon atoms, and cycloalkylalkyl having 4 to 7 carbon atoms in the chain and 3-6 carbon atoms in the ring; wherein said substituents on R 1 are selected from the group consisting of halogen, hydroxyl, amino, alkyl having 1-6 carbon atoms, azido, cyano, and carboxyl.
Claim 3
Dependent Claim
18 words
A compound according to claim 1 wherein R 1 is methyl, phenyl, benzyl, ethyl, cyclopropyl, propyl and isopropyl.
Claim 4
Dependent Claim
15 words
A compound according to claim 2 wherein R 1 is methyl having the structure ##STR84##
Claim 5
Dependent Claim
14 words
A compound having the formula: ##STR85## wherein R is H or CH 3 .
Claim 6
Dependent Claim
14 words
A compound having the formula: ##STR85## wherein R is H or CH 3 .
Claim 7
Dependent Claim
25 words
An antibiotic pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, 2, 3, or 4 and a pharmaceutically carrier therefor.
References Cited (Backward Citations)
US3950357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-19 | 1984-02-18 | 1984-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-19 | 1988-02-18 | 1988-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-19 | 1992-02-18 | 1992-08-19 | $7700.00 | Window Closed / Lapsed |