US4217458A
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US
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Acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
Assignee: ER Squibb and Sons LLC
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Filing: 1979-08-24
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Granted: 1980-08-12
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Expires: 1999-08-24
Abstract
Abstract New acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids having the general formula ##STR1## are useful as hypotensive agents.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Michael E. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:09
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/68; C07D211/72; C07D211/78; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
94 words
A compound of the formula ##STR19## wherein R and R 2 each is hydrogen or lower alkyl; R 1 is hydrogen, hydroxy, halogen or lower alkoxy; R 4 is lower alkyl of 1 to 6 carbons, cycloalkyl of 3 to 7 carbons, ##STR20## p is zero, one or two; R 5 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, or halogen; X is O or S; m and n each is zero or one; and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
94 words
A compound of the formula ##STR19## wherein R and R 2 each is hydrogen or lower alkyl; R 1 is hydrogen, hydroxy, halogen or lower alkoxy; R 4 is lower alkyl of 1 to 6 carbons, cycloalkyl of 3 to 7 carbons, ##STR20## p is zero, one or two; R 5 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, or halogen; X is O or S; m and n each is zero or one; and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
18 words
A compound as in claim 1 wherein ##STR21## is lower alkanoyl of 2 to 4 carbons or benzoyl.
Claim 4
Dependent Claim
10 words
A compound as in claim 2 wherein m is 0.
Claim 5
Dependent Claim
10 words
A compound as in claim 2 wherein m is 1.
Claim 6
Dependent Claim
26 words
A compound as in claim 3 wherein R, R 1 and R 2 each is hydrogen, and ##STR22## is lower alkanoyl of 2 to 4 carbons.
Claim 7
Dependent Claim
10 words
A compound as in claim 5 wherein ##STR23## is acetyl.
Claim 8
Dependent Claim
24 words
A compound as in claim 3 wherein R, R 1 , and R 2 each is hydrogen, ##STR24## is acetyl; and n is zero.
Claim 9
Dependent Claim
25 words
A compound as in claim 3 wherein R and R 1 each is hydrogen; R 2 is methyl; ##STR25## is acetyl; and n is one.
References Cited (Backward Citations)
US4129566A
Cited
US4154942A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-12 | 1984-02-11 | 1984-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-12 | 1988-02-11 | 1988-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-12 | 1992-02-11 | 1992-08-12 | $7700.00 | Window Closed / Lapsed |